DegronMD

Uniprot ID: Q5XXA6

Source protein: Anoctamin-1

Source gene: ANO1

Class: CBL_PTK

Location: 4:11

E3 ligase: CBL

DEGRON score: 0.702

ASA_SCORE: 94.1875

COIL: 0.8438

CONS_SCORE: 0.3167

DSS_SCORE: 0.4802

HELIX: 0.1295

FCONS_SCORE: 1.0646

RIG_SCORE: 0.7754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R15C	TCGA-15-0742	GBM	TCGA	NEKYSTLP	CBL_PTK	0.2222
p.R15C	DO13623	GBM	ICGC	NEKYSTLP	CBL_PTK	0.2222
p.P11T	TCGA-FS-A1ZA	SKCM	TCGA	NEKYSTLP	CBL_PTK	0.7031
p.P11T	DO37551	SKCM	ICGC	NEKYSTLP	CBL_PTK	0.7031
p.S8L	DO231583	LINC	ICGC	NEKYSTLP	CBL_PTK	0.8778
p.D14G	SIDM01045	Endometrial Carcinoma	GDSC	NEKYSTLP	CBL_PTK	0.25
p.D14G	ACH-000978	Endometrial/Uterine Cancer	CCLE	NEKYSTLP	CBL_PTK	0.25
p.D14G	EN	endometrium	COSMIC	NEKYSTLP	CBL_PTK	0.25
p.Y16N	NCI-H1651	lung	COSMIC	NEKYSTLP	CBL_PTK	0.1944
p.G10S	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	NEKYSTLP	CBL_PTK	0.6993
p.P17L	HCC1395	breast	COSMIC	NEKYSTLP	CBL_PTK	0.1667
p.A13V	NCI-H630	large_intestine	COSMIC	NEKYSTLP	CBL_PTK	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5XXA6	Anoctamin-1	CBL_PTK	4:11	NEKYSTLP	CBL	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons