DegronMD

Uniprot ID: P19021

Source protein: Peptidyl-glycine alpha-amidating monooxygenase

Source gene: PAM

Class: DEG_Kelch_Keap1_1

Location: 762:767

E3 ligase: KEAP1

DEGRON score: 0.7875

ASA_SCORE: 58.7333

COIL: 0.8165

CONS_SCORE: 0.5525

DSS_SCORE: 0.161

HELIX: 0.0165

FCONS_SCORE: 1.1567

RIG_SCORE: 0.7991

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S764F	TCGA-B5-A11E	UCEC	TCGA	NFSNGE	DEG_Kelch_Keap1_1	0.7982
p.S764F	TCGA-ER-A194	SKCM	TCGA	NFSNGE	DEG_Kelch_Keap1_1	0.7982
p.R776C	TCGA-D5-6930	COAD	TCGA	NFSNGE	DEG_Kelch_Keap1_1	0.0833
p.R776C	TCGA-EO-A22U	UCEC	TCGA	NFSNGE	DEG_Kelch_Keap1_1	0.0833
p.D770A	TCGA-EO-A3B0	UCEC	TCGA	NFSNGE	DEG_Kelch_Keap1_1	0.25
p.E754D	DO1094	BRCA	ICGC	NFSNGE	DEG_Kelch_Keap1_1	0.1111
p.P767S	DO42256	UCEC	ICGC	NFSNGE	DEG_Kelch_Keap1_1	0.6752
p.M761I	SIDM00588	Oral Cavity Carcinoma	GDSC	NFSNGE	DEG_Kelch_Keap1_1	0.3056
p.M761I	ACH-000546	Head and Neck Cancer	CCLE	NFSNGE	DEG_Kelch_Keap1_1	0.3056
p.M761I	HSC-4	upper_aerodigestive_tract	COSMIC	NFSNGE	DEG_Kelch_Keap1_1	0.3056
p.N765S	SIDM00351	Oral Cavity Carcinoma	GDSC	NFSNGE	DEG_Kelch_Keap1_1	0.5958
p.N765S	ACH-002029	Head and Neck Cancer	CCLE	NFSNGE	DEG_Kelch_Keap1_1	0.5958
p.N765S	SAS	upper_aerodigestive_tract	COSMIC	NFSNGE	DEG_Kelch_Keap1_1	0.5958
p.P769L	SNU-1040	large_intestine	COSMIC	NFSNGE	DEG_Kelch_Keap1_1	0.2778
p.S755L	HCC2998	large_intestine	COSMIC	NFSNGE	DEG_Kelch_Keap1_1	0.1389
p.E752D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	NFSNGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19021	Peptidyl-glycine alpha-amidating monooxygenase	DEG_Kelch_Keap1_1	762:767	NFSNGE	KEAP1	0.7875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons