DegronMD - P19021(PAM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R62C	TCGA-14-1451	GBM	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2778
p.R62C	TCGA-AN-A046	BRCA	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2778
p.R62C	DO1285	BRCA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2778
p.R62C	DO13384	GBM	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2778
p.A58V	TCGA-AP-A051	UCEC	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1667
p.A58V	DO42673	UCEC	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1667
p.D56Y	TCGA-B5-A11E	UCEC	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1111
p.D56Y	DO41644	UCEC	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1111
p.S764F	TCGA-B5-A11E	UCEC	TCGA	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation altering degron motif	0.7982
p.S764F	TCGA-ER-A194	SKCM	TCGA	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation altering degron motif	0.7982
p.R80P	TCGA-BH-A0AW	BRCA	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.R80P	DO5005	BRCA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.S55L	TCGA-D3-A3MV	SKCM	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.S55L	DO37727	SKCM	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.R776C	TCGA-D5-6930	COAD	TCGA	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation rewiring degron network	0.0833
p.R776C	TCGA-EO-A22U	UCEC	TCGA	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation rewiring degron network	0.0833
p.D770A	TCGA-EO-A3B0	UCEC	TCGA	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation rewiring degron network	0.25
p.S71Y	TCGA-EP-A2KB	LIHC	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation altering degron motif	0.712
p.S71Y	DO22932	LIHC	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation altering degron motif	0.712
p.M63I	TCGA-GS-A9U3	DLBC	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.3056
p.M63I	DO219919	DLBC	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.3056
p.D72N	TCGA-IA-A40U	KIRP	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.3056
p.D72N	DO44482	KIRP	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.3056
p.E754D	DO1094	BRCA	ICGC	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation rewiring degron network	0.1111
p.D60Y	DO229029	LICA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2222
p.R80L	DO229024	LICA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.R62P	DO52686	MALY	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2778
p.A76T	DO222502	MELA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1944
p.G72E	DO229453	SKCA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.3056
p.R80Q	DO229502	SKCA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.H70Y	DO229248	THCA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation altering degron motif	0.7229
p.P767S	DO42256	UCEC	ICGC	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation altering degron motif	0.6752
p.F65S	DO42600	UCEC	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	64:71	Mutation altering degron motif	0.7982
p.M761I	SIDM00588	Oral Cavity Carcinoma	GDSC	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation rewiring degron network	0.3056
p.M761I	ACH-000546	Head and Neck Cancer	CCLE	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation rewiring degron network	0.3056
p.M761I	HSC-4	upper aerodigestive tract	COSMIC	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation rewiring degron network	0.3056
p.N765S	SIDM00351	Oral Cavity Carcinoma	GDSC	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation altering degron motif	0.5958
p.N765S	ACH-002029	Head and Neck Cancer	CCLE	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation altering degron motif	0.5958
p.N765S	SAS	upper aerodigestive tract	COSMIC	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation altering degron motif	0.5958
p.P769L	SNU-1040	large intestine	COSMIC	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation rewiring degron network	0.2778
p.S755L	HCC2998	large intestine	COSMIC	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation rewiring degron network	0.1389
p.E752D	Daudi	haematopoietic and lymphoid tissue	COSMIC	NFSNGE	DEG_Kelch_Keap1_1	762:767	Mutation rewiring degron network	0.0556

Kaplan plot for PAM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAM

UniProt ID: P19021

Entrez ID: 5066

Protein name: Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAM in