DegronMD

Uniprot ID: P19021

Source protein: Peptidyl-glycine alpha-amidating monooxygenase

Source gene: PAM

Class: DEG_SCF_FBW7_1

Location: 64:71

E3 ligase: FBXW7

DEGRON score: 0.527

ASA_SCORE: 69.325

COIL: 0.8884

CONS_SCORE: 0.4383

DSS_SCORE: 0.2983

HELIX: 0.0063

FCONS_SCORE: 1.1696

RIG_SCORE: 0.7439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R62C	TCGA-14-1451	GBM	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	0.2778
p.R62C	TCGA-AN-A046	BRCA	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	0.2778
p.R62C	DO1285	BRCA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.2778
p.R62C	DO13384	GBM	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.2778
p.A58V	TCGA-AP-A051	UCEC	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	0.1667
p.A58V	DO42673	UCEC	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.1667
p.D56Y	TCGA-B5-A11E	UCEC	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	0.1111
p.D56Y	DO41644	UCEC	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.1111
p.R80P	TCGA-BH-A0AW	BRCA	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	0.0833
p.R80P	DO5005	BRCA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.0833
p.S55L	TCGA-D3-A3MV	SKCM	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	0.0833
p.S55L	DO37727	SKCM	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.0833
p.S71Y	TCGA-EP-A2KB	LIHC	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	0.712
p.S71Y	DO22932	LIHC	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.712
p.M63I	TCGA-GS-A9U3	DLBC	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	0.3056
p.M63I	DO219919	DLBC	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.3056
p.D72N	TCGA-IA-A40U	KIRP	TCGA	PGVTPKQS	DEG_SCF_FBW7_1	0.3056
p.D72N	DO44482	KIRP	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.3056
p.D60Y	DO229029	LICA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.2222
p.R80L	DO229024	LICA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.0833
p.R62P	DO52686	MALY	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.2778
p.A76T	DO222502	MELA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.1944
p.G72E	DO229453	SKCA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.3056
p.R80Q	DO229502	SKCA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.0833
p.H70Y	DO229248	THCA	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.7229
p.F65S	DO42600	UCEC	ICGC	PGVTPKQS	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19021	Peptidyl-glycine alpha-amidating monooxygenase	DEG_SCF_FBW7_1	64:71	PGVTPKQS	FBXW7	0.527	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons