DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NFTATYTRHP
Uniprot ID:
Q9H6S1
Source protein:
5-azacytidine-induced protein 2
Source gene:
AZI2
Class:
CBL_PTK
Location:
277:286
E3 ligase:
CBL
DEGRON score:
0.8873
ASA_SCORE:
94.69
COIL:
0.877
CONS_SCORE:
0.5071
DSS_SCORE:
0.356
HELIX:
0.0893
FCONS_SCORE:
1.0066
RIG_SCORE:
0.778
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.F278V
TCGA-CA-6717
COAD
TCGA
NFTATYTRHP
CBL_PTK
0.5957
p.F278V
DO8264
COAD
ICGC
NFTATYTRHP
CBL_PTK
0.5957
p.F278V
SIDM00118
Colorectal Carcinoma
GDSC
NFTATYTRHP
CBL_PTK
0.5957
p.F278V
ACH-001081
Colon/Colorectal Cancer
CCLE
NFTATYTRHP
CBL_PTK
0.5957
p.F278V
HCC2998
large_intestine
COSMIC
NFTATYTRHP
CBL_PTK
0.5957
p.F278L
DO222798
COCA
ICGC
NFTATYTRHP
CBL_PTK
0.587
p.S270R
DO229026
LICA
ICGC
NFTATYTRHP
CBL_PTK
0.5833
p.S270R
DO229032
LICA
ICGC
NFTATYTRHP
CBL_PTK
0.5833
p.P286S
DO220885
MELA
ICGC
NFTATYTRHP
CBL_PTK
0.6752
p.L288F
ACH-000868
Lung Cancer
CCLE
NFTATYTRHP
CBL_PTK
0.2778
Drug responses associated with AZI2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NFTATYTRHP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H6S1
5-azacytidine-induced protein 2
CBL_PTK
277:286
NFTATYTRHP
CBL
0.8873
More...
