DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NGIPTYTLAP
Uniprot ID:
Q6IQ32
Source protein:
Activity-dependent neuroprotector homeobox protein 2
Source gene:
ADNP2
Class:
CBL_PTK
Location:
610:619
E3 ligase:
CBL
DEGRON score:
0.9769
ASA_SCORE:
87.81
COIL:
0.9353
CONS_SCORE:
0.9156
DSS_SCORE:
0.241
HELIX:
0.0175
FCONS_SCORE:
1.3128
RIG_SCORE:
0.7891
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A618V
TCGA-21-1076
LUSC
TCGA
NGIPTYTLAP
CBL_PTK
0.5825
p.A618V
TCGA-FI-A2F4
UCEC
TCGA
NGIPTYTLAP
CBL_PTK
0.5825
p.A618V
DO26599
LUSC
ICGC
NGIPTYTLAP
CBL_PTK
0.5825
p.A618V
DO43434
UCEC
ICGC
NGIPTYTLAP
CBL_PTK
0.5825
p.G629E
TCGA-DA-A3F8
SKCM
TCGA
NGIPTYTLAP
CBL_PTK
0.0556
p.G629E
DO37418
SKCM
ICGC
NGIPTYTLAP
CBL_PTK
0.0556
p.G611W
TCGA-EE-A29L
SKCM
TCGA
NGIPTYTLAP
CBL_PTK
0.6714
p.G611W
DO37835
SKCM
ICGC
NGIPTYTLAP
CBL_PTK
0.6714
p.P627L
TCGA-GF-A3OT
SKCM
TCGA
NGIPTYTLAP
CBL_PTK
0.1111
p.P627L
DO47288
SKCM
ICGC
NGIPTYTLAP
CBL_PTK
0.1111
p.P613Q
TCGA-GN-A26C
SKCM
TCGA
NGIPTYTLAP
CBL_PTK
0.5924
p.P613Q
DO37782
SKCM
ICGC
NGIPTYTLAP
CBL_PTK
0.5924
p.P604H
SIDM01951
Colorectal Carcinoma
GDSC
NGIPTYTLAP
CBL_PTK
0.1667
p.V620M
SIDM00330
Neuroblastoma
GDSC
NGIPTYTLAP
CBL_PTK
0.3056
p.V620M
ACH-001355
Neuroblastoma
CCLE
NGIPTYTLAP
CBL_PTK
0.3056
p.V620M
LAN-6
autonomic_ganglia
COSMIC
NGIPTYTLAP
CBL_PTK
0.3056
Drug responses associated with ADNP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NGIPTYTLAP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6IQ32
Activity-dependent neuroprotector homeobox protein 2
CBL_PTK
610:619
NGIPTYTLAP
CBL
0.9769
More...
