DegronMD - Q6IQ32(ADNP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A618V	TCGA-21-1076	LUSC	TCGA	NGIPTYTLAP	CBL_PTK	610:619	Mutation altering degron motif	0.5825
p.A618V	TCGA-FI-A2F4	UCEC	TCGA	NGIPTYTLAP	CBL_PTK	610:619	Mutation altering degron motif	0.5825
p.A618V	DO26599	LUSC	ICGC	NGIPTYTLAP	CBL_PTK	610:619	Mutation altering degron motif	0.5825
p.A618V	DO43434	UCEC	ICGC	NGIPTYTLAP	CBL_PTK	610:619	Mutation altering degron motif	0.5825
p.A443V	TCGA-5M-AAT6	COAD	TCGA	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation altering degron motif	0.5825
p.A443V	DO223703	COAD	ICGC	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation altering degron motif	0.5825
p.A457V	TCGA-AP-A059	UCEC	TCGA	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation rewiring degron network	0.0833
p.A457V	DO41361	UCEC	ICGC	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation rewiring degron network	0.0833
p.G629E	TCGA-DA-A3F8	SKCM	TCGA	NGIPTYTLAP	CBL_PTK	610:619	Mutation rewiring degron network	0.0556
p.G629E	DO37418	SKCM	ICGC	NGIPTYTLAP	CBL_PTK	610:619	Mutation rewiring degron network	0.0556
p.G611W	TCGA-EE-A29L	SKCM	TCGA	NGIPTYTLAP	CBL_PTK	610:619	Mutation altering degron motif	0.6714
p.G611W	DO37835	SKCM	ICGC	NGIPTYTLAP	CBL_PTK	610:619	Mutation altering degron motif	0.6714
p.P627L	TCGA-GF-A3OT	SKCM	TCGA	NGIPTYTLAP	CBL_PTK	610:619	Mutation rewiring degron network	0.1111
p.P627L	DO47288	SKCM	ICGC	NGIPTYTLAP	CBL_PTK	610:619	Mutation rewiring degron network	0.1111
p.P613Q	TCGA-GN-A26C	SKCM	TCGA	NGIPTYTLAP	CBL_PTK	610:619	Mutation altering degron motif	0.5924
p.P613Q	DO37782	SKCM	ICGC	NGIPTYTLAP	CBL_PTK	610:619	Mutation altering degron motif	0.5924
p.R442W	TCGA-GN-A8LN	SKCM	TCGA	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation altering degron motif	0.7523
p.R442W	DO233115	GACA	ICGC	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation altering degron motif	0.7523
p.R442W	DO51262	SKCM	ICGC	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation altering degron motif	0.7523
p.S439F	DO222875	MELA	ICGC	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation altering degron motif	0.7982
p.P604H	SIDM01951	Colorectal Carcinoma	GDSC	NGIPTYTLAP	CBL_PTK	610:619	Mutation rewiring degron network	0.1667
p.V620M	SIDM00330	Neuroblastoma	GDSC	NGIPTYTLAP	CBL_PTK	610:619	Mutation rewiring degron network	0.3056
p.V620M	ACH-001355	Neuroblastoma	CCLE	NGIPTYTLAP	CBL_PTK	610:619	Mutation rewiring degron network	0.3056
p.V620M	LAN-6	autonomic ganglia	COSMIC	NGIPTYTLAP	CBL_PTK	610:619	Mutation rewiring degron network	0.3056
p.S434T	SIDM00232	Kidney Carcinoma	GDSC	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation rewiring degron network	0.1944
p.S434T	NCC021	kidney	COSMIC	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation rewiring degron network	0.1944
p.T455N	SIDM00783	Colorectal Carcinoma	GDSC	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation rewiring degron network	0.1389
p.T455N	HCT-116	large intestine	COSMIC	SVSRAVPSGV	DEG_COP1_1	439:448	Mutation rewiring degron network	0.1389

Kaplan plot for ADNP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADNP2

UniProt ID: Q6IQ32

Entrez ID: 22850

Protein name: Activity-dependent neuroprotector homeobox protein 2 (ADNP homeobox protein 2) (Zinc finger protein 508)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADNP2 in