DegronMD

Uniprot ID: Q6IQ32

Source protein: Activity-dependent neuroprotector homeobox protein 2

Source gene: ADNP2

Class: DEG_COP1_1

Location: 439:448

E3 ligase: COP1

DEGRON score: 0.9847

ASA_SCORE: 81.7

COIL: 0.9172

CONS_SCORE: 0.3626

DSS_SCORE: 0.3293

HELIX: 0.0185

FCONS_SCORE: 1.297

RIG_SCORE: 0.7326

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A443V	TCGA-5M-AAT6	COAD	TCGA	SVSRAVPSGV	DEG_COP1_1	0.5825
p.A443V	DO223703	COAD	ICGC	SVSRAVPSGV	DEG_COP1_1	0.5825
p.A457V	TCGA-AP-A059	UCEC	TCGA	SVSRAVPSGV	DEG_COP1_1	0.0833
p.A457V	DO41361	UCEC	ICGC	SVSRAVPSGV	DEG_COP1_1	0.0833
p.R442W	TCGA-GN-A8LN	SKCM	TCGA	SVSRAVPSGV	DEG_COP1_1	0.7523
p.R442W	DO233115	GACA	ICGC	SVSRAVPSGV	DEG_COP1_1	0.7523
p.R442W	DO51262	SKCM	ICGC	SVSRAVPSGV	DEG_COP1_1	0.7523
p.S439F	DO222875	MELA	ICGC	SVSRAVPSGV	DEG_COP1_1	0.7982
p.S434T	SIDM00232	Kidney Carcinoma	GDSC	SVSRAVPSGV	DEG_COP1_1	0.1944
p.S434T	NCC021	kidney	COSMIC	SVSRAVPSGV	DEG_COP1_1	0.1944
p.T455N	SIDM00783	Colorectal Carcinoma	GDSC	SVSRAVPSGV	DEG_COP1_1	0.1389
p.T455N	HCT-116	large_intestine	COSMIC	SVSRAVPSGV	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IQ32	Activity-dependent neuroprotector homeobox protein 2	DEG_COP1_1	439:448	SVSRAVPSGV	COP1	0.9847	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons