DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
NGLFYSSGP
Uniprot ID:
Q53FD0
Source protein:
Zinc finger C2HC domain-containing protein 1C
Source gene:
ZC2HC1C
Class:
CBL_PTK
Location:
105:113
E3 ligase:
CBL
DEGRON score:
0.9752
ASA_SCORE:
65.4222
COIL:
0.7313
CONS_SCORE:
0.3569
DSS_SCORE:
0.5708
HELIX:
0.0479
FCONS_SCORE:
0.8666
RIG_SCORE:
0.6573
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S100Y
TCGA-AX-A2HC
UCEC
TCGA
NGLFYSSGP
CBL_PTK
0.1944
p.S100Y
DO41572
UCEC
ICGC
NGLFYSSGP
CBL_PTK
0.1944
p.S110L
TCGA-B5-A11E
UCEC
TCGA
NGLFYSSGP
CBL_PTK
0.7667
p.S110L
DO41644
UCEC
ICGC
NGLFYSSGP
CBL_PTK
0.7667
p.G104E
DO6351
CLLE
ICGC
NGLFYSSGP
CBL_PTK
0.3056
p.W116R
DO233179
GACA
ICGC
NGLFYSSGP
CBL_PTK
0.25
p.G112V
DO229028
LICA
ICGC
NGLFYSSGP
CBL_PTK
0.6421
p.P96S
DO218856
SKCA
ICGC
NGLFYSSGP
CBL_PTK
0.0833
p.S98G
SIDM01123
Prostate Carcinoma
GDSC
NGLFYSSGP
CBL_PTK
0.1389
p.S98G
SIDM01322
Oral Cavity Carcinoma
GDSC
NGLFYSSGP
CBL_PTK
0.1389
p.S110W
SIDM01180
Hepatocellular Carcinoma
GDSC
NGLFYSSGP
CBL_PTK
0.7874
p.P113H
ACH-001610
Brain Cancer
CCLE
NGLFYSSGP
CBL_PTK
0.7694
Drug responses associated with ZC2HC1C mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NGLFYSSGP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q53FD0
Zinc finger C2HC domain-containing protein 1C
CBL_PTK
105:113
NGLFYSSGP
CBL
0.9752
More...
