DegronMD - Q53FD0(ZC2HC1C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S149L	TCGA-A6-6653	COAD	TCGA	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation altering degron motif	0.7667
p.S149L	TCGA-B5-A3FA	UCEC	TCGA	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation altering degron motif	0.7667
p.S149L	DO10373	COAD	ICGC	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation altering degron motif	0.7667
p.S149L	DO52402	UCEC	ICGC	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation altering degron motif	0.7667
p.G153C	TCGA-AN-A0AK	BRCA	TCGA	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation altering degron motif	0.76
p.G153C	DO1608	BRCA	ICGC	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation altering degron motif	0.76
p.S100Y	TCGA-AX-A2HC	UCEC	TCGA	NGLFYSSGP	CBL_PTK	105:113	Mutation rewiring degron network	0.1944
p.S100Y	DO41572	UCEC	ICGC	NGLFYSSGP	CBL_PTK	105:113	Mutation rewiring degron network	0.1944
p.S110L	TCGA-B5-A11E	UCEC	TCGA	NGLFYSSGP	CBL_PTK	105:113	Mutation altering degron motif	0.7667
p.S110L	DO41644	UCEC	ICGC	NGLFYSSGP	CBL_PTK	105:113	Mutation altering degron motif	0.7667
p.L141F	TCGA-BS-A0UV	UCEC	TCGA	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation rewiring degron network	0.1111
p.L141F	DO42793	UCEC	ICGC	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation rewiring degron network	0.1111
p.T152A	TCGA-E6-A1LX	UCEC	TCGA	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation altering degron motif	0.7139
p.T152A	DO41020	UCEC	ICGC	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation altering degron motif	0.7139
p.V163G	TCGA-HZ-8001	PAAD	TCGA	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation rewiring degron network	0.0833
p.V163G	DO32796	PAAD	ICGC	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation rewiring degron network	0.0833
p.G104E	DO6351	CLLE	ICGC	NGLFYSSGP	CBL_PTK	105:113	Mutation rewiring degron network	0.3056
p.W116R	DO233179	GACA	ICGC	NGLFYSSGP	CBL_PTK	105:113	Mutation rewiring degron network	0.25
p.G112V	DO229028	LICA	ICGC	NGLFYSSGP	CBL_PTK	105:113	Mutation altering degron motif	0.6421
p.D158N	DO222413	MELA	ICGC	SCSTGE	DEG_Kelch_Keap1_1	149:154	Mutation rewiring degron network	0.2222
p.P96S	DO218856	SKCA	ICGC	NGLFYSSGP	CBL_PTK	105:113	Mutation rewiring degron network	0.0833
p.S98G	SIDM01123	Prostate Carcinoma	GDSC	NGLFYSSGP	CBL_PTK	105:113	Mutation rewiring degron network	0.1389
p.S98G	SIDM01322	Oral Cavity Carcinoma	GDSC	NGLFYSSGP	CBL_PTK	105:113	Mutation rewiring degron network	0.1389
p.S110W	SIDM01180	Hepatocellular Carcinoma	GDSC	NGLFYSSGP	CBL_PTK	105:113	Mutation altering degron motif	0.7874
p.P113H	ACH-001610	Brain Cancer	CCLE	NGLFYSSGP	CBL_PTK	105:113	Mutation altering degron motif	0.7694

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC2HC1C

UniProt ID: Q53FD0

Entrez ID: 79696

Protein name: Zinc finger C2HC domain-containing protein 1C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC2HC1C in