DegronMD

Uniprot ID: Q53FD0

Source protein: Zinc finger C2HC domain-containing protein 1C

Source gene: ZC2HC1C

Class: DEG_Kelch_Keap1_1

Location: 149:154

E3 ligase: KEAP1

DEGRON score: 0.9777

ASA_SCORE: 71.4833

COIL: 0.8888

CONS_SCORE: 0.5054

DSS_SCORE: 0.566

HELIX: 0.0572

FCONS_SCORE: 0.9414

RIG_SCORE: 0.614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S149L	TCGA-A6-6653	COAD	TCGA	SCSTGE	DEG_Kelch_Keap1_1	0.7667
p.S149L	TCGA-B5-A3FA	UCEC	TCGA	SCSTGE	DEG_Kelch_Keap1_1	0.7667
p.S149L	DO10373	COAD	ICGC	SCSTGE	DEG_Kelch_Keap1_1	0.7667
p.S149L	DO52402	UCEC	ICGC	SCSTGE	DEG_Kelch_Keap1_1	0.7667
p.G153C	TCGA-AN-A0AK	BRCA	TCGA	SCSTGE	DEG_Kelch_Keap1_1	0.76
p.G153C	DO1608	BRCA	ICGC	SCSTGE	DEG_Kelch_Keap1_1	0.76
p.L141F	TCGA-BS-A0UV	UCEC	TCGA	SCSTGE	DEG_Kelch_Keap1_1	0.1111
p.L141F	DO42793	UCEC	ICGC	SCSTGE	DEG_Kelch_Keap1_1	0.1111
p.T152A	TCGA-E6-A1LX	UCEC	TCGA	SCSTGE	DEG_Kelch_Keap1_1	0.7139
p.T152A	DO41020	UCEC	ICGC	SCSTGE	DEG_Kelch_Keap1_1	0.7139
p.V163G	TCGA-HZ-8001	PAAD	TCGA	SCSTGE	DEG_Kelch_Keap1_1	0.0833
p.V163G	DO32796	PAAD	ICGC	SCSTGE	DEG_Kelch_Keap1_1	0.0833
p.D158N	DO222413	MELA	ICGC	SCSTGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53FD0	Zinc finger C2HC domain-containing protein 1C	DEG_Kelch_Keap1_1	149:154	SCSTGE	KEAP1	0.9777	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons