DegronMD

Uniprot ID: Q9NXZ1

Source protein: Sarcoma antigen 1

Source gene: SAGE1

Class: CBL_PTK

Location: 290:297

E3 ligase: CBL

DEGRON score: 0.9152

ASA_SCORE: 70.9125

COIL: 0.6704

CONS_SCORE: 0.4545

DSS_SCORE: 0.3976

HELIX: 0.0333

FCONS_SCORE: 0.8063

RIG_SCORE: 0.7171

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M305T	TCGA-55-7724	LUAD	TCGA	NGLYSTVP	CBL_PTK	0.1111
p.M305T	DO45373	LUAD	ICGC	NGLYSTVP	CBL_PTK	0.1111
p.P285S	TCGA-77-8145	LUSC	TCGA	NGLYSTVP	CBL_PTK	0.1944
p.P285S	DO26496	LUSC	ICGC	NGLYSTVP	CBL_PTK	0.1944
p.E306K	TCGA-85-8350	LUSC	TCGA	NGLYSTVP	CBL_PTK	0.0833
p.E306K	DO45492	LUSC	ICGC	NGLYSTVP	CBL_PTK	0.0833
p.E303K	TCGA-86-8278	LUAD	TCGA	NGLYSTVP	CBL_PTK	0.1667
p.E303K	DO26308	LUAD	ICGC	NGLYSTVP	CBL_PTK	0.1667
p.N290D	TCGA-94-8490	LUSC	TCGA	NGLYSTVP	CBL_PTK	0.5821
p.N290D	DO52021	LUSC	ICGC	NGLYSTVP	CBL_PTK	0.5821
p.G281R	TCGA-W3-AA1W	SKCM	TCGA	NGLYSTVP	CBL_PTK	0.0833
p.G281R	DO51277	SKCM	ICGC	NGLYSTVP	CBL_PTK	0.0833
p.G291D	DO233140	GACA	ICGC	NGLYSTVP	CBL_PTK	0.6087
p.A296T	DO228978	LICA	ICGC	NGLYSTVP	CBL_PTK	0.7139
p.A296T	DO41644	UCEC	ICGC	NGLYSTVP	CBL_PTK	0.7139
p.G291V	DO229029	LICA	ICGC	NGLYSTVP	CBL_PTK	0.6421
p.V300F	DO229036	LICA	ICGC	NGLYSTVP	CBL_PTK	0.25
p.A282D	DO231573	LINC	ICGC	NGLYSTVP	CBL_PTK	0.1111
p.G281E	DO220891	MELA	ICGC	NGLYSTVP	CBL_PTK	0.0833
p.S294F	DO222837	MELA	ICGC	NGLYSTVP	CBL_PTK	0.7982
p.S294F	DO229456	SKCA	ICGC	NGLYSTVP	CBL_PTK	0.7982
p.T289I	DO41871	UCEC	ICGC	NGLYSTVP	CBL_PTK	0.3056
p.A281S	DO43907	UCEC	ICGC	NGLYSTVP	CBL_PTK	0.0833
p.A280V	SIDM00973	Melanoma	GDSC	NGLYSTVP	CBL_PTK	0.0556
p.A280V	ACH-000827	Skin Cancer	CCLE	NGLYSTVP	CBL_PTK	0.0556
p.P297S	SIDM00545	Melanoma	GDSC	NGLYSTVP	CBL_PTK	0.6752
p.P297S	ACH-000987	Skin Cancer	CCLE	NGLYSTVP	CBL_PTK	0.6752
p.P297S	Mewo	skin	COSMIC	NGLYSTVP	CBL_PTK	0.6752
p.V296I	SIDM00449	B-Lymphoblastic Leukemia	GDSC	NGLYSTVP	CBL_PTK	0.5965
p.V296I	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	NGLYSTVP	CBL_PTK	0.5965
p.V296I	ACH-000744	Lung Cancer	CCLE	NGLYSTVP	CBL_PTK	0.5965
p.V296I	ACH-000922	Leukemia	CCLE	NGLYSTVP	CBL_PTK	0.5965
p.V296I	ACH-001814	Bone Cancer	CCLE	NGLYSTVP	CBL_PTK	0.5965
p.V296I	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	NGLYSTVP	CBL_PTK	0.5965
p.V296I	NCI-H1623	lung	COSMIC	NGLYSTVP	CBL_PTK	0.5965
p.G291C	ACH-001973	Metastasis	CCLE	NGLYSTVP	CBL_PTK	0.6489
p.E302G	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	NGLYSTVP	CBL_PTK	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NGLYSTVP

Degron related mutations and impact score

Drug responses associated with SAGE1 mutations

All proteins holding degron of NGLYSTVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXZ1	Sarcoma antigen 1	CBL_PTK	290:297	NGLYSTVP	CBL	0.9152	More...