DegronMD - Q9NXZ1(SAGE1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D825N	TCGA-33-4586	LUSC	TCGA	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0833
p.D825N	DO27318	LUSC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0833
p.P5T	TCGA-49-AAR9	LUAD	TCGA	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation rewiring degron network	0.1667
p.P5T	DO218921	LUAD	ICGC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation rewiring degron network	0.1667
p.M305T	TCGA-55-7724	LUAD	TCGA	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.1111
p.M305T	DO45373	LUAD	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.1111
p.P285S	TCGA-77-8145	LUSC	TCGA	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.1944
p.P285S	DO26496	LUSC	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.1944
p.D825Y	TCGA-78-7536	LUAD	TCGA	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0833
p.D825Y	DO26414	LUAD	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0833
p.E306K	TCGA-85-8350	LUSC	TCGA	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.0833
p.E306K	DO45492	LUSC	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.0833
p.E303K	TCGA-86-8278	LUAD	TCGA	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.1667
p.E303K	DO26308	LUAD	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.1667
p.N290D	TCGA-94-8490	LUSC	TCGA	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.5821
p.N290D	DO52021	LUSC	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.5821
p.K821T	TCGA-B5-A11N	UCEC	TCGA	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation substituting flanking lysine	0.3056
p.K821T	DO41458	UCEC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation substituting flanking lysine	0.3056
p.S816F	TCGA-F5-6814	READ	TCGA	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation altering degron motif	0.7982
p.S816F	DO36556	READ	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation altering degron motif	0.7982
p.G281R	TCGA-W3-AA1W	SKCM	TCGA	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.0833
p.G281R	DO51277	SKCM	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.0833
p.M803I	DO4766	BRCA	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.1667
p.P11L	DO229003	COCA	ICGC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation altering degron motif	0.6471
p.P11L	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation altering degron motif	0.6471
p.P11L	SIDM00273	Glioblastoma	GDSC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation altering degron motif	0.6471
p.P11L	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation altering degron motif	0.6471
p.P11L	SIDM01782	Oral Cavity Carcinoma	GDSC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation altering degron motif	0.6471
p.P11L	SIDM01662	Plasma Cell Myeloma	GDSC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation altering degron motif	0.6471
p.P11L	GI-1	central nervous system	COSMIC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation altering degron motif	0.6471
p.P11L	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation altering degron motif	0.6471
p.G291D	DO233140	GACA	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.6087
p.I823F	DO231983	LICA	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.1389
p.A296T	DO228978	LICA	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.7139
p.A296T	DO41644	UCEC	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.7139
p.G291V	DO229029	LICA	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.6421
p.L805F	DO229029	LICA	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.2222
p.V23L	DO229036	LICA	ICGC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation rewiring degron network	0.1389
p.V300F	DO229036	LICA	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.25
p.A282D	DO231573	LINC	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.1111
p.L805S	DO230550	LUSC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.2222
p.L805S	DO52365	LUSC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.2222
p.L805S	DO231056	LUSC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.2222
p.L805S	DO231049	LUSC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.2222
p.A19S	DO231047	LUSC	ICGC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation rewiring degron network	0.25
p.G281E	DO220891	MELA	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.0833
p.S294F	DO222837	MELA	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.7982
p.S294F	DO229456	SKCA	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.7982
p.T289I	DO41871	UCEC	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.3056
p.A281S	DO43907	UCEC	ICGC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.0833
p.D826Y	SIDM00578	Neuroblastoma	GDSC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0556
p.D826Y	ACH-000804	Neuroblastoma	CCLE	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0556
p.A280V	SIDM00973	Melanoma	GDSC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.0556
p.A280V	ACH-000827	Skin Cancer	CCLE	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.0556
p.P297S	SIDM00545	Melanoma	GDSC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.6752
p.P297S	ACH-000987	Skin Cancer	CCLE	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.6752
p.P297S	Mewo	skin	COSMIC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.6752
p.Q10K	SIDM00506	Small Cell Lung Carcinoma	GDSC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation rewiring degron network	0.3056
p.Q10K	ACH-000508	Lung Cancer	CCLE	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation rewiring degron network	0.3056
p.Q10K	COR-L88	lung	COSMIC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation rewiring degron network	0.3056
p.V296I	SIDM00449	B-Lymphoblastic Leukemia	GDSC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.5965
p.V296I	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.5965
p.V296I	ACH-000744	Lung Cancer	CCLE	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.5965
p.V296I	ACH-000922	Leukemia	CCLE	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.5965
p.V296I	ACH-001814	Bone Cancer	CCLE	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.5965
p.V296I	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.5965
p.V296I	NCI-H1623	lung	COSMIC	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.5965
p.N26D	SIDM00878	Breast Carcinoma	GDSC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation rewiring degron network	0.0556
p.N26D	ACH-000930	Breast Cancer	CCLE	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation rewiring degron network	0.0556
p.N26D	HCC1569	breast	COSMIC	PTPPEE	DEG_SCF_FBW7_2	11:16	Mutation rewiring degron network	0.0556
p.I823S	SIDM00118	Colorectal Carcinoma	GDSC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.1389
p.I823S	ACH-001081	Colon/Colorectal Cancer	CCLE	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.1389
p.I823S	HCC2998	large intestine	COSMIC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.1389
p.G291C	ACH-001973	Metastasis	CCLE	NGLYSTVP	CBL_PTK	290:297	Mutation altering degron motif	0.6489
p.E302G	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	NGLYSTVP	CBL_PTK	290:297	Mutation rewiring degron network	0.1944
p.D826A	CAPAN-1	pancreas	COSMIC	VPNTPQIS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SAGE1

UniProt ID: Q9NXZ1

Entrez ID: 55511

Protein name: Sarcoma antigen 1 (Cancer/testis antigen 14) (CT14)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SAGE1 in