DegronMD

Uniprot ID: Q9NXZ1

Source protein: Sarcoma antigen 1

Source gene: SAGE1

Class: DEG_SCF_FBW7_1

Location: 809:816

E3 ligase: FBXW7

DEGRON score: 0.9534

ASA_SCORE: 79.4375

COIL: 0.9145

CONS_SCORE: 0.2536

DSS_SCORE: 0.3941

HELIX: 0.0313

FCONS_SCORE: 0.6766

RIG_SCORE: 0.7529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D825N	TCGA-33-4586	LUSC	TCGA	VPNTPQIS	DEG_SCF_FBW7_1	0.0833
p.D825N	DO27318	LUSC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.0833
p.D825Y	TCGA-78-7536	LUAD	TCGA	VPNTPQIS	DEG_SCF_FBW7_1	0.0833
p.D825Y	DO26414	LUAD	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.0833
p.K821T	TCGA-B5-A11N	UCEC	TCGA	VPNTPQIS	DEG_SCF_FBW7_1	0.3056
p.K821T	DO41458	UCEC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.3056
p.S816F	TCGA-F5-6814	READ	TCGA	VPNTPQIS	DEG_SCF_FBW7_1	0.7982
p.S816F	DO36556	READ	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.7982
p.M803I	DO4766	BRCA	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.1667
p.I823F	DO231983	LICA	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.1389
p.L805F	DO229029	LICA	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.2222
p.L805S	DO230550	LUSC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.2222
p.L805S	DO52365	LUSC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.2222
p.L805S	DO231056	LUSC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.2222
p.L805S	DO231049	LUSC	ICGC	VPNTPQIS	DEG_SCF_FBW7_1	0.2222
p.D826Y	SIDM00578	Neuroblastoma	GDSC	VPNTPQIS	DEG_SCF_FBW7_1	0.0556
p.D826Y	ACH-000804	Neuroblastoma	CCLE	VPNTPQIS	DEG_SCF_FBW7_1	0.0556
p.I823S	SIDM00118	Colorectal Carcinoma	GDSC	VPNTPQIS	DEG_SCF_FBW7_1	0.1389
p.I823S	ACH-001081	Colon/Colorectal Cancer	CCLE	VPNTPQIS	DEG_SCF_FBW7_1	0.1389
p.I823S	HCC2998	large_intestine	COSMIC	VPNTPQIS	DEG_SCF_FBW7_1	0.1389
p.D826A	CAPAN-1	pancreas	COSMIC	VPNTPQIS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXZ1	Sarcoma antigen 1	DEG_SCF_FBW7_1	809:816	VPNTPQIS	FBXW7	0.9534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons