DegronMD

Uniprot ID: Q9NXZ1

Source protein: Sarcoma antigen 1

Source gene: SAGE1

Class: DEG_SCF_FBW7_2

Location: 11:16

E3 ligase: FBXW7

DEGRON score: 0.9973

ASA_SCORE: 84.1167

COIL: 0.8122

CONS_SCORE: 0.5176

DSS_SCORE: 0.6541

HELIX: 0.1583

FCONS_SCORE: 1.2008

RIG_SCORE: 0.6184

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P5T	TCGA-49-AAR9	LUAD	TCGA	PTPPEE	DEG_SCF_FBW7_2	0.1667
p.P5T	DO218921	LUAD	ICGC	PTPPEE	DEG_SCF_FBW7_2	0.1667
p.P11L	DO229003	COCA	ICGC	PTPPEE	DEG_SCF_FBW7_2	0.6471
p.P11L	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PTPPEE	DEG_SCF_FBW7_2	0.6471
p.P11L	SIDM00273	Glioblastoma	GDSC	PTPPEE	DEG_SCF_FBW7_2	0.6471
p.P11L	SIDM01727	Chronic Myelogenous Leukemia	GDSC	PTPPEE	DEG_SCF_FBW7_2	0.6471
p.P11L	SIDM01782	Oral Cavity Carcinoma	GDSC	PTPPEE	DEG_SCF_FBW7_2	0.6471
p.P11L	SIDM01662	Plasma Cell Myeloma	GDSC	PTPPEE	DEG_SCF_FBW7_2	0.6471
p.P11L	GI-1	central_nervous_system	COSMIC	PTPPEE	DEG_SCF_FBW7_2	0.6471
p.P11L	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPPEE	DEG_SCF_FBW7_2	0.6471
p.V23L	DO229036	LICA	ICGC	PTPPEE	DEG_SCF_FBW7_2	0.1389
p.A19S	DO231047	LUSC	ICGC	PTPPEE	DEG_SCF_FBW7_2	0.25
p.Q10K	SIDM00506	Small Cell Lung Carcinoma	GDSC	PTPPEE	DEG_SCF_FBW7_2	0.3056
p.Q10K	ACH-000508	Lung Cancer	CCLE	PTPPEE	DEG_SCF_FBW7_2	0.3056
p.Q10K	COR-L88	lung	COSMIC	PTPPEE	DEG_SCF_FBW7_2	0.3056
p.N26D	SIDM00878	Breast Carcinoma	GDSC	PTPPEE	DEG_SCF_FBW7_2	0.0556
p.N26D	ACH-000930	Breast Cancer	CCLE	PTPPEE	DEG_SCF_FBW7_2	0.0556
p.N26D	HCC1569	breast	COSMIC	PTPPEE	DEG_SCF_FBW7_2	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons