DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPPEE
Uniprot ID:
A6NJ88
Source protein:
Putative SAGE1-like protein
Source gene:
SAGE2P
Class:
DEG_SCF_FBW7_2
Location:
52:57
E3 ligase:
FBXW7
DEGRON score:
0.5672
ASA_SCORE:
78.6833
COIL:
0.8082
CONS_SCORE:
0
DSS_SCORE:
0.5875
HELIX:
0.124
FCONS_SCORE:
0
RIG_SCORE:
0.6434
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SAGE2P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPPEE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NXZ1
Sarcoma antigen 1
DEG_SCF_FBW7_2
11:16
PTPPEE
FBXW7
0.9973
More...
A6NJ88
Putative SAGE1-like protein
DEG_SCF_FBW7_2
52:57
PTPPEE
FBXW7
0.5672
More...