DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NHGNHYSDGP
Uniprot ID:
Q93008
Source protein:
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
Source gene:
USP9X
Class:
CBL_PTK
Location:
989:998
E3 ligase:
CBL
DEGRON score:
0.8892
ASA_SCORE:
72.5
COIL:
0.8546
CONS_SCORE:
0.2865
DSS_SCORE:
0.6825
HELIX:
0.073
FCONS_SCORE:
0.8664
RIG_SCORE:
0.512
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H993N
TCGA-B5-A1MR
UCEC
TCGA
NHGNHYSDGP
CBL_PTK
0.6312
p.H993N
DO41758
UCEC
ICGC
NHGNHYSDGP
CBL_PTK
0.6312
p.E1001G
DO228404
BRCA
ICGC
NHGNHYSDGP
CBL_PTK
0.25
p.G991V
DO229018
LICA
ICGC
NHGNHYSDGP
CBL_PTK
0.6421
p.C1005F
DO229018
LICA
ICGC
NHGNHYSDGP
CBL_PTK
0.1389
p.C1005F
DO229036
LICA
ICGC
NHGNHYSDGP
CBL_PTK
0.1389
p.P987L
DO218850
SKCA
ICGC
NHGNHYSDGP
CBL_PTK
0.2778
Drug responses associated with USP9X mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NHGNHYSDGP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q93008
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
CBL_PTK
989:998
NHGNHYSDGP
CBL
0.8892
More...
