DegronMD

Uniprot ID: A8MUV8

Source protein: Putative zinc finger protein 727

Source gene: ZNF727

Class: DEG_APCC_TPR_1

Location: 497:499

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6007

ASA_SCORE: 119.5667

COIL: 0.9027

CONS_SCORE: 0

DSS_SCORE: 0.9201

HELIX: 0.0607

FCONS_SCORE: 0

RIG_SCORE: 0.8038

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q493H	TCGA-AA-3977	COAD	TCGA	NIR	DEG_APCC_TPR_1	0.2222
p.Q493H	DO8730	COAD	ICGC	NIR	DEG_APCC_TPR_1	0.2222
p.K487N	TCGA-AP-A056	UCEC	TCGA	NIR	DEG_APCC_TPR_1	0.1667
p.K487N	DO43971	UCEC	ICGC	NIR	DEG_APCC_TPR_1	0.1667
p.K487N	SIDM00095	Glioblastoma	GDSC	NIR	DEG_APCC_TPR_1	0.1667
p.S492F	TCGA-BS-A0UF	UCEC	TCGA	NIR	DEG_APCC_TPR_1	0.1944
p.S492F	DO41488	UCEC	ICGC	NIR	DEG_APCC_TPR_1	0.1944
p.N497S	SIDM00193	Colorectal Carcinoma	GDSC	NIR	DEG_APCC_TPR_1	0.5958
p.G490C	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	NIR	DEG_APCC_TPR_1	0.1389
p.G490C	ACH-000807	Brain Cancer	CCLE	NIR	DEG_APCC_TPR_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BR9	Zinc finger and BTB domain-containing protein 8A	DEG_APCC_TPR_1	439:441	NIR	APC,CDC20,FZR1	0.6823	More...
A8MUV8	Putative zinc finger protein 727	DEG_APCC_TPR_1	497:499	NIR	APC,CDC20,FZR1	0.6007	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons