DegronMD

Uniprot ID: Q96BR9

Source protein: Zinc finger and BTB domain-containing protein 8A

Source gene: ZBTB8A

Class: DEG_APCC_TPR_1

Location: 439:441

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6823

ASA_SCORE: 116.8333

COIL: 0.7953

CONS_SCORE: 0.4442

DSS_SCORE: 0.9315

HELIX: 0.1927

FCONS_SCORE: 0.7086

RIG_SCORE: 0.7304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P438S	TCGA-BR-8680	STAD	TCGA	NIR	DEG_APCC_TPR_1	0.3056
p.P438S	DO47769	STAD	ICGC	NIR	DEG_APCC_TPR_1	0.3056
p.P438L	TCGA-QC-A7B5	SARC	TCGA	NIR	DEG_APCC_TPR_1	0.3056
p.P438L	DO220239	SARC	ICGC	NIR	DEG_APCC_TPR_1	0.3056
p.E435K	DO51044	PRAD	ICGC	NIR	DEG_APCC_TPR_1	0.2222
p.E430V	SIDM00480	Ovarian Carcinoma	GDSC	NIR	DEG_APCC_TPR_1	0.0833
p.E430V	ACH-000704	Ovarian Cancer	CCLE	NIR	DEG_APCC_TPR_1	0.0833
p.E430V	OAW-42	ovary	COSMIC	NIR	DEG_APCC_TPR_1	0.0833
p.E429D	SIDM00220	Ovarian Carcinoma	GDSC	NIR	DEG_APCC_TPR_1	0.0556
p.E429D	ACH-000962	Ovarian Cancer	CCLE	NIR	DEG_APCC_TPR_1	0.0556
p.E429D	ACH-001145	Ovarian Cancer	CCLE	NIR	DEG_APCC_TPR_1	0.0556
p.E429D	OC-314	ovary	COSMIC	NIR	DEG_APCC_TPR_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BR9	Zinc finger and BTB domain-containing protein 8A	DEG_APCC_TPR_1	439:441	NIR	APC,CDC20,FZR1	0.6823	More...
A8MUV8	Putative zinc finger protein 727	DEG_APCC_TPR_1	497:499	NIR	APC,CDC20,FZR1	0.6007	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons