DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NKENG
Uniprot ID:
Q8IWR0
Source protein:
Zinc finger CCCH domain-containing protein 7A
Source gene:
ZC3H7A
Class:
DEG_APCC_KENBOX_2
Location:
837:841
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5385
ASA_SCORE:
105.2
COIL:
0.805
CONS_SCORE:
0.4878
DSS_SCORE:
0.5675
HELIX:
0.1648
FCONS_SCORE:
0.8326
RIG_SCORE:
0.6437
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ZC3H7A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NKENG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IWR0
Zinc finger CCCH domain-containing protein 7A
DEG_APCC_KENBOX_2
837:841
NKENG
APC,CDC20,FZR1
0.5385
More...