DegronMD

Uniprot ID: Q14517

Source protein: Protocadherin Fat 1

Source gene: FAT1

Class: CBL_PTK

Location: 4238:4246

E3 ligase: CBL

DEGRON score: 0.9792

ASA_SCORE: 91.2889

COIL: 0.8482

CONS_SCORE: 0.3601

DSS_SCORE: 0.4374

HELIX: 0.1158

FCONS_SCORE: 0.905

RIG_SCORE: 0.7497

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D4244H	TCGA-B9-A69E	KIRP	TCGA	NKNIYSDIP	CBL_PTK	0.6577
p.D4244H	DO44513	KIRP	ICGC	NKNIYSDIP	CBL_PTK	0.6577
p.Q4248H	TCGA-DF-A2KN	UCEC	TCGA	NKNIYSDIP	CBL_PTK	0.2778
p.Q4248H	DO223282	UCEC	ICGC	NKNIYSDIP	CBL_PTK	0.2778
p.I4245M	DO233737	GACA	ICGC	NKNIYSDIP	CBL_PTK	0.6507
p.P4246L	DO222546	MELA	ICGC	NKNIYSDIP	CBL_PTK	0.7582
p.P4247H	SIDM00965	Small Cell Lung Carcinoma	GDSC	NKNIYSDIP	CBL_PTK	0.3056
p.P4247H	ACH-000800	Lung Cancer	CCLE	NKNIYSDIP	CBL_PTK	0.3056
p.P4247H	NCI-H446	lung	COSMIC	NKNIYSDIP	CBL_PTK	0.3056
p.L4228M	SIDM00844	Burkitt's Lymphoma	GDSC	NKNIYSDIP	CBL_PTK	0.0556
p.L4228M	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	NKNIYSDIP	CBL_PTK	0.0556
p.Y4242H	SIDM01451	Pancreatic Carcinoma	GDSC	NKNIYSDIP	CBL_PTK	0.834
p.Y4242H	ACH-000933	Pancreatic Cancer	CCLE	NKNIYSDIP	CBL_PTK	0.834
p.L4230M	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	NKNIYSDIP	CBL_PTK	0.1111
p.P4249H	NCI-H446	lung	COSMIC	NKNIYSDIP	CBL_PTK	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14517	Protocadherin Fat 1	CBL_PTK	4238:4246	NKNIYSDIP	CBL	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons