DegronMD

Uniprot ID: Q9H8W5

Source protein: Tripartite motif-containing protein 45

Source gene: TRIM45

Class: CBL_PTK

Location: 358:366

E3 ligase: CBL

DEGRON score: 0.537

ASA_SCORE: 90.9222

COIL: 0.8342

CONS_SCORE: 0.459

DSS_SCORE: 0.2627

HELIX: 0.1384

FCONS_SCORE: 0.7947

RIG_SCORE: 0.7922

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R365C	TCGA-B5-A5OC	UCEC	TCGA	NKVQYSTRP	CBL_PTK	0.719
p.R373C	TCGA-CM-6165	COAD	TCGA	NKVQYSTRP	CBL_PTK	0.1389
p.P366S	TCGA-D3-A3MR	SKCM	TCGA	NKVQYSTRP	CBL_PTK	0.6752
p.P366S	SIDM01240	Melanoma	GDSC	NKVQYSTRP	CBL_PTK	0.6752
p.P366S	ACH-001002	Skin Cancer	CCLE	NKVQYSTRP	CBL_PTK	0.6752
p.P366S	451Lu	skin	COSMIC	NKVQYSTRP	CBL_PTK	0.6752
p.R373H	TCGA-HJ-7597	STAD	TCGA	NKVQYSTRP	CBL_PTK	0.1389
p.R356Q	DO228483	BRCA	ICGC	NKVQYSTRP	CBL_PTK	0.2778
p.R356Q	DO229013	COCA	ICGC	NKVQYSTRP	CBL_PTK	0.2778
p.R356Q	DO234285	ESAD	ICGC	NKVQYSTRP	CBL_PTK	0.2778
p.R356Q	DO229047	LICA	ICGC	NKVQYSTRP	CBL_PTK	0.2778
p.R356Q	DO231169	LUSC	ICGC	NKVQYSTRP	CBL_PTK	0.2778
p.G376D	DO229010	COCA	ICGC	NKVQYSTRP	CBL_PTK	0.0556
p.A371V	DO38727	STAD	ICGC	NKVQYSTRP	CBL_PTK	0.6389
p.R353Q	SIDM01265	Plasma Cell Myeloma	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM01090	Colorectal Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM00454	Rhabdomyosarcoma	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM00928	Breast Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM00849	Kidney Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM01147	Gastric Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM00930	Osteosarcoma	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM00431	T-Lymphoblastic Leukemia	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM00863	Burkitt's Lymphoma	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM00785	Acute Myeloid Leukemia	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.R353Q	SIDM01525	Acute Myeloid Leukemia	GDSC	NKVQYSTRP	CBL_PTK	0.1944
p.K371N	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	0.6389
p.K371N	ACH-000824	Esophageal Cancer	CCLE	NKVQYSTRP	CBL_PTK	0.6389
p.K371N	KYSE-510	oesophagus	COSMIC	NKVQYSTRP	CBL_PTK	0.6389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKVQYSTRP

Degron related mutations and impact score

Drug responses associated with TRIM45 mutations

All proteins holding degron of NKVQYSTRP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8W5	Tripartite motif-containing protein 45	CBL_PTK	358:366	NKVQYSTRP	CBL	0.537	More...