DegronMD - Q9H8W5(TRIM45)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A570T	TCGA-A5-A0G2	UCEC	TCGA	PRSLLRTVA	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.3056
p.R365C	TCGA-B5-A5OC	UCEC	TCGA	NKVQYSTRP	CBL_PTK	358:366	Mutation altering degron motif	0.719
p.R373C	TCGA-CM-6165	COAD	TCGA	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1389
p.P366S	TCGA-D3-A3MR	SKCM	TCGA	NKVQYSTRP	CBL_PTK	358:366	Mutation altering degron motif	0.6752
p.P366S	SIDM01240	Melanoma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation altering degron motif	0.6752
p.P366S	ACH-001002	Skin Cancer	CCLE	NKVQYSTRP	CBL_PTK	358:366	Mutation altering degron motif	0.6752
p.P366S	451Lu	skin	COSMIC	NKVQYSTRP	CBL_PTK	358:366	Mutation altering degron motif	0.6752
p.R373H	TCGA-HJ-7597	STAD	TCGA	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1389
p.R356Q	DO228483	BRCA	ICGC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.2778
p.R356Q	DO229013	COCA	ICGC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.2778
p.R356Q	DO234285	ESAD	ICGC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.2778
p.R356Q	DO229047	LICA	ICGC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.2778
p.R356Q	DO231169	LUSC	ICGC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.2778
p.T577A	DO230342	COCA	ICGC	PRSLLRTVA	DEG_APCC_DBOX_1	571:579	Mutation altering degron motif	0.6028
p.G376D	DO229010	COCA	ICGC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.0556
p.Q568H	DO233072	GACA	ICGC	PRSLLRTVA	DEG_APCC_DBOX_1	571:579	Mutation rewiring degron network	0.25
p.A371V	DO38727	STAD	ICGC	NKVQYSTRP	CBL_PTK	358:366	Mutation blocking ubiquitination signal	0.6389
p.R353Q	SIDM01265	Plasma Cell Myeloma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM01090	Colorectal Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM00454	Rhabdomyosarcoma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM00928	Breast Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM00849	Kidney Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM01147	Gastric Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM00930	Osteosarcoma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM00431	T-Lymphoblastic Leukemia	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM00863	Burkitt's Lymphoma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM00721	Small Cell Lung Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM00785	Acute Myeloid Leukemia	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM01686	Chronic Myelogenous Leukemia	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.R353Q	SIDM01525	Acute Myeloid Leukemia	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation rewiring degron network	0.1944
p.K371N	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	NKVQYSTRP	CBL_PTK	358:366	Mutation blocking ubiquitination signal	0.6389
p.K371N	ACH-000824	Esophageal Cancer	CCLE	NKVQYSTRP	CBL_PTK	358:366	Mutation blocking ubiquitination signal	0.6389
p.K371N	KYSE-510	oesophagus	COSMIC	NKVQYSTRP	CBL_PTK	358:366	Mutation blocking ubiquitination signal	0.6389

Kaplan plot for TRIM45 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRIM45

UniProt ID: Q9H8W5

Entrez ID: 80263

Protein name: Tripartite motif-containing protein 45 (RING finger protein 99)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRIM45 in