DegronMD

Uniprot ID: Q9H8W5

Source protein: Tripartite motif-containing protein 45

Source gene: TRIM45

Class: DEG_APCC_DBOX_1

Location: 571:579

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9044

ASA_SCORE: 76.5333

COIL: 0.4497

CONS_SCORE: 0.4384

DSS_SCORE: 0.5903

HELIX: 0.307

FCONS_SCORE: 1.2793

RIG_SCORE: 0.8136

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A570T	TCGA-A5-A0G2	UCEC	TCGA	PRSLLRTVA	DEG_APCC_DBOX_1	0.3056
p.T577A	DO230342	COCA	ICGC	PRSLLRTVA	DEG_APCC_DBOX_1	0.6028
p.Q568H	DO233072	GACA	ICGC	PRSLLRTVA	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8W5	Tripartite motif-containing protein 45	DEG_APCC_DBOX_1	571:579	PRSLLRTVA	APC,CDC20,FZR1	0.9044	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons