DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NLAEYTGCP
Uniprot ID:
Q8WUJ1
Source protein:
Neuferricin
Source gene:
CYB5D2
Class:
CBL_PTK
Location:
246:254
E3 ligase:
CBL
DEGRON score:
0.9819
ASA_SCORE:
60.8111
COIL:
0.7523
CONS_SCORE:
0.4912
DSS_SCORE:
0.3582
HELIX:
0.0474
FCONS_SCORE:
1.1454
RIG_SCORE:
0.7237
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L264I
TCGA-19-5956
GBM
TCGA
NLAEYTGCP
CBL_PTK
0.0556
p.L264I
DO13863
GBM
ICGC
NLAEYTGCP
CBL_PTK
0.0556
p.H236N
TCGA-24-1474
OV
TCGA
NLAEYTGCP
CBL_PTK
0.0556
p.H236N
DO31919
OV
ICGC
NLAEYTGCP
CBL_PTK
0.0556
p.P254Q
TCGA-EE-A2M8
SKCM
TCGA
NLAEYTGCP
CBL_PTK
0.7035
p.P254Q
DO38075
SKCM
ICGC
NLAEYTGCP
CBL_PTK
0.7035
p.F262L
DO23222
LINC
ICGC
NLAEYTGCP
CBL_PTK
0.1111
p.C253W
ACH-000971
Colon/Colorectal Cancer
CCLE
NLAEYTGCP
CBL_PTK
0.5889
Drug responses associated with CYB5D2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NLAEYTGCP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WUJ1
Neuferricin
CBL_PTK
246:254
NLAEYTGCP
CBL
0.9819
More...
