DegronMD

Uniprot ID: Q6PJI9

Source protein: GATOR complex protein WDR59

Source gene: WDR59

Class: CBL_PTK

Location: 596:604

E3 ligase: CBL

DEGRON score: 0.9411

ASA_SCORE: 69.0444

COIL: 0.7633

CONS_SCORE: 0.2772

DSS_SCORE: 0.5092

HELIX: 0.1343

FCONS_SCORE: 0.9537

RIG_SCORE: 0.6893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R606L	TCGA-22-5472	LUSC	TCGA	NLRLYSGSP	CBL_PTK	0.2778
p.R606L	DO27421	LUSC	ICGC	NLRLYSGSP	CBL_PTK	0.2778
p.S601N	TCGA-B5-A11U	UCEC	TCGA	NLRLYSGSP	CBL_PTK	0.7069
p.S601N	DO40804	UCEC	ICGC	NLRLYSGSP	CBL_PTK	0.7069
p.R598C	TCGA-DF-A2KV	UCEC	TCGA	NLRLYSGSP	CBL_PTK	0.719
p.R598C	TCGA-OR-A5LB	ACC	TCGA	NLRLYSGSP	CBL_PTK	0.719
p.R598C	DO219771	UCEC	ICGC	NLRLYSGSP	CBL_PTK	0.719
p.Q611H	TCGA-ER-A19P	SKCM	TCGA	NLRLYSGSP	CBL_PTK	0.1389
p.Q611H	DO47623	SKCM	ICGC	NLRLYSGSP	CBL_PTK	0.1389
p.R590C	TCGA-F1-6177	STAD	TCGA	NLRLYSGSP	CBL_PTK	0.1667
p.R590C	DO38727	STAD	ICGC	NLRLYSGSP	CBL_PTK	0.1667
p.A593V	DO222843	MELA	ICGC	NLRLYSGSP	CBL_PTK	0.25
p.A593S	DO50662	ORCA	ICGC	NLRLYSGSP	CBL_PTK	0.25
p.P594S	SIDM00007	Other Solid Cancers	GDSC	NLRLYSGSP	CBL_PTK	0.2778
p.P594S	ACH-001550	Skin Cancer	CCLE	NLRLYSGSP	CBL_PTK	0.2778
p.P594S	MCC13	skin	COSMIC	NLRLYSGSP	CBL_PTK	0.2778
p.R590L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	NLRLYSGSP	CBL_PTK	0.1667
p.R590L	ACH-000951	Lung Cancer	CCLE	NLRLYSGSP	CBL_PTK	0.1667
p.R590L	NCI-H2342	lung	COSMIC	NLRLYSGSP	CBL_PTK	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PJI9	GATOR complex protein WDR59	CBL_PTK	596:604	NLRLYSGSP	CBL	0.9411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons