DegronMD - Q6PJI9(WDR59)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F218L	TCGA-06-5416	GBM	TCGA	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.1667
p.F218L	DO10880	GBM	ICGC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.1667
p.R606L	TCGA-22-5472	LUSC	TCGA	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.2778
p.R606L	DO27421	LUSC	ICGC	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.2778
p.S601N	TCGA-B5-A11U	UCEC	TCGA	NLRLYSGSP	CBL_PTK	596:604	Mutation altering degron motif	0.7069
p.S601N	DO40804	UCEC	ICGC	NLRLYSGSP	CBL_PTK	596:604	Mutation altering degron motif	0.7069
p.W219C	TCGA-D3-A2J6	SKCM	TCGA	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.1944
p.W219C	DO37901	SKCM	ICGC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.1944
p.R598C	TCGA-DF-A2KV	UCEC	TCGA	NLRLYSGSP	CBL_PTK	596:604	Mutation altering degron motif	0.719
p.R598C	TCGA-OR-A5LB	ACC	TCGA	NLRLYSGSP	CBL_PTK	596:604	Mutation altering degron motif	0.719
p.R598C	DO219771	UCEC	ICGC	NLRLYSGSP	CBL_PTK	596:604	Mutation altering degron motif	0.719
p.P236L	TCGA-ER-A19M	SKCM	TCGA	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.2222
p.P236L	DO37798	SKCM	ICGC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.2222
p.Q611H	TCGA-ER-A19P	SKCM	TCGA	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.1389
p.Q611H	DO47623	SKCM	ICGC	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.1389
p.R590C	TCGA-F1-6177	STAD	TCGA	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.1667
p.R590C	DO38727	STAD	ICGC	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.1667
p.S215Y	DO229019	LICA	ICGC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.0833
p.A593V	DO222843	MELA	ICGC	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.25
p.A593S	DO50662	ORCA	ICGC	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.25
p.R225W	SIDM00216	Colorectal Carcinoma	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation altering degron motif	0.8634
p.R225W	ACH-000989	Colon/Colorectal Cancer	CCLE	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation altering degron motif	0.8634
p.R225W	SNU-175	large intestine	COSMIC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation altering degron motif	0.8634
p.P232S	SIDM00336	Melanoma	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation altering degron motif	0.5641
p.P232S	ACH-000881	Skin Cancer	CCLE	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation altering degron motif	0.5641
p.P232S	MEL-JUSO	skin	COSMIC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation altering degron motif	0.5641
p.P594S	SIDM00007	Other Solid Cancers	GDSC	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.2778
p.P594S	ACH-001550	Skin Cancer	CCLE	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.2778
p.P594S	MCC13	skin	COSMIC	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.2778
p.N229S	SIDM00869	Non-Cancerous	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation altering degron motif	0.5958
p.N229S	SIDM00538	Esophageal Carcinoma	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation altering degron motif	0.5958
p.N229S	SIDM00621	Ewing's Sarcoma	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation altering degron motif	0.5958
p.R590L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.1667
p.R590L	ACH-000951	Lung Cancer	CCLE	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.1667
p.R590L	NCI-H2342	lung	COSMIC	NLRLYSGSP	CBL_PTK	596:604	Mutation rewiring degron network	0.1667
p.R222H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.2778
p.R222H	ACH-001127	Leukemia	CCLE	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.2778
p.R222H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.2778
p.L242V	NCI-H2196	lung	COSMIC	PRKYLNILP	DEG_APCC_DBOX_1	224:232	Mutation rewiring degron network	0.0556

Kaplan plot for WDR59 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR59

UniProt ID: Q6PJI9

Entrez ID: 79726

Protein name: GATOR complex protein WDR59 (WD repeat-containing protein 59)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR59 in