DegronMD

Uniprot ID: Q6PJI9

Source protein: GATOR complex protein WDR59

Source gene: WDR59

Class: DEG_APCC_DBOX_1

Location: 224:232

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6472

ASA_SCORE: 73.0556

COIL: 0.4036

CONS_SCORE: 0.4322

DSS_SCORE: 0.0825

HELIX: 0.0258

FCONS_SCORE: 0.6778

RIG_SCORE: 0.8785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F218L	TCGA-06-5416	GBM	TCGA	PRKYLNILP	DEG_APCC_DBOX_1	0.1667
p.F218L	DO10880	GBM	ICGC	PRKYLNILP	DEG_APCC_DBOX_1	0.1667
p.W219C	TCGA-D3-A2J6	SKCM	TCGA	PRKYLNILP	DEG_APCC_DBOX_1	0.1944
p.W219C	DO37901	SKCM	ICGC	PRKYLNILP	DEG_APCC_DBOX_1	0.1944
p.P236L	TCGA-ER-A19M	SKCM	TCGA	PRKYLNILP	DEG_APCC_DBOX_1	0.2222
p.P236L	DO37798	SKCM	ICGC	PRKYLNILP	DEG_APCC_DBOX_1	0.2222
p.S215Y	DO229019	LICA	ICGC	PRKYLNILP	DEG_APCC_DBOX_1	0.0833
p.R225W	SIDM00216	Colorectal Carcinoma	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	0.8634
p.R225W	ACH-000989	Colon/Colorectal Cancer	CCLE	PRKYLNILP	DEG_APCC_DBOX_1	0.8634
p.R225W	SNU-175	large_intestine	COSMIC	PRKYLNILP	DEG_APCC_DBOX_1	0.8634
p.P232S	SIDM00336	Melanoma	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	0.5641
p.P232S	ACH-000881	Skin Cancer	CCLE	PRKYLNILP	DEG_APCC_DBOX_1	0.5641
p.P232S	MEL-JUSO	skin	COSMIC	PRKYLNILP	DEG_APCC_DBOX_1	0.5641
p.N229S	SIDM00869	Non-Cancerous	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	0.5958
p.N229S	SIDM00538	Esophageal Carcinoma	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	0.5958
p.N229S	SIDM00621	Ewing's Sarcoma	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	0.5958
p.R222H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRKYLNILP	DEG_APCC_DBOX_1	0.2778
p.R222H	ACH-001127	Leukemia	CCLE	PRKYLNILP	DEG_APCC_DBOX_1	0.2778
p.R222H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PRKYLNILP	DEG_APCC_DBOX_1	0.2778
p.L242V	NCI-H2196	lung	COSMIC	PRKYLNILP	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PJI9	GATOR complex protein WDR59	DEG_APCC_DBOX_1	224:232	PRKYLNILP	APC,CDC20,FZR1	0.6472	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons