DegronMD

Uniprot ID: Q9P2D6

Source protein: Protein FAM135A

Source gene: FAM135A

Class: CBL_PTK

Location: 1004:1013

E3 ligase: CBL

DEGRON score: 0.5133

ASA_SCORE: 85.8

COIL: 0.6452

CONS_SCORE: 0.2398

DSS_SCORE: 0.4429

HELIX: 0.294

FCONS_SCORE: 1.0637

RIG_SCORE: 0.785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1011Q	TCGA-44-3918	LUAD	TCGA	NLTQMYSEIP	CBL_PTK	0.5633
p.E1011Q	DO23732	LUAD	ICGC	NLTQMYSEIP	CBL_PTK	0.5633
p.P1013S	TCGA-D9-A149	SKCM	TCGA	NLTQMYSEIP	CBL_PTK	0.6752
p.P1013S	DO37420	SKCM	ICGC	NLTQMYSEIP	CBL_PTK	0.6752
p.L1005P	TCGA-DI-A1BU	UCEC	TCGA	NLTQMYSEIP	CBL_PTK	0.6471
p.L1005P	DO42023	UCEC	ICGC	NLTQMYSEIP	CBL_PTK	0.6471
p.K997T	TCGA-E6-A1LX	UCEC	TCGA	NLTQMYSEIP	CBL_PTK	0.25
p.N1004H	TCGA-ND-A4WC	UCS	TCGA	NLTQMYSEIP	CBL_PTK	0.7423
p.G1022S	TCGA-VQ-A924	STAD	TCGA	NLTQMYSEIP	CBL_PTK	0.0833
p.S997P	DO17323	KIRC	ICGC	NLTQMYSEIP	CBL_PTK	0.25
p.S1017I	SIDM01165	Pancreatic Carcinoma	GDSC	NLTQMYSEIP	CBL_PTK	0.2222
p.S1017I	SW1990	pancreas	COSMIC	NLTQMYSEIP	CBL_PTK	0.2222
p.G1022D	SIDM01133	Other Solid Cancers	GDSC	NLTQMYSEIP	CBL_PTK	0.0833
p.K1023R	ACH-000467	Colon/Colorectal Cancer	CCLE	NLTQMYSEIP	CBL_PTK	0.0556
p.K1023R	HCC-56	large_intestine	COSMIC	NLTQMYSEIP	CBL_PTK	0.0556
p.V1008A	ACH-000801	Skin Cancer	CCLE	NLTQMYSEIP	CBL_PTK	0.6936
p.Y1007H	ACH-002062	Lymphoma	CCLE	NLTQMYSEIP	CBL_PTK	0.7229
p.Y1007H	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	NLTQMYSEIP	CBL_PTK	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2D6	Protein FAM135A	CBL_PTK	1004:1013	NLTQMYSEIP	CBL	0.5133	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons