DegronMD - Q9P2D6(FAM135A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A780V	TCGA-2W-A8YY	CESC	TCGA	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.1667
p.A780V	DO223732	CESC	ICGC	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.1667
p.E1011Q	TCGA-44-3918	LUAD	TCGA	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation altering degron motif	0.5633
p.E1011Q	DO23732	LUAD	ICGC	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation altering degron motif	0.5633
p.S778F	TCGA-AA-3977	COAD	TCGA	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.2222
p.R766T	TCGA-AG-4021	READ	TCGA	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.25
p.E775K	TCGA-BK-A0C9	UCEC	TCGA	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.3056
p.E775K	DO41253	UCEC	ICGC	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.3056
p.P1013S	TCGA-D9-A149	SKCM	TCGA	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation altering degron motif	0.6752
p.P1013S	DO37420	SKCM	ICGC	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation altering degron motif	0.6752
p.T761A	TCGA-DI-A1BU	UCEC	TCGA	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.1111
p.T761A	DO42023	UCEC	ICGC	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.1111
p.L1005P	TCGA-DI-A1BU	UCEC	TCGA	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation altering degron motif	0.6471
p.L1005P	DO42023	UCEC	ICGC	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation altering degron motif	0.6471
p.K997T	TCGA-E6-A1LX	UCEC	TCGA	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation substituting flanking lysine	0.25
p.N1004H	TCGA-ND-A4WC	UCS	TCGA	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation altering degron motif	0.7423
p.G1022S	TCGA-VQ-A924	STAD	TCGA	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation rewiring degron network	0.0833
p.S997P	DO17323	KIRC	ICGC	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation substituting flanking lysine	0.25
p.T765A	DO26442	LUSC	ICGC	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.2222
p.G766V	DO37462	SKCM	ICGC	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.25
p.S1017I	SIDM01165	Pancreatic Carcinoma	GDSC	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation rewiring degron network	0.2222
p.S1017I	SW1990	pancreas	COSMIC	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation rewiring degron network	0.2222
p.G1022D	SIDM01133	Other Solid Cancers	GDSC	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation rewiring degron network	0.0833
p.K1023R	ACH-000467	Colon/Colorectal Cancer	CCLE	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation rewiring degron network	0.0556
p.K1023R	HCC-56	large intestine	COSMIC	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation rewiring degron network	0.0556
p.V1008A	ACH-000801	Skin Cancer	CCLE	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation altering degron motif	0.6936
p.Y1007H	ACH-002062	Lymphoma	CCLE	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation altering degron motif	0.7229
p.Y1007H	SLVL	haematopoietic and lymphoid tissue	COSMIC	NLTQMYSEIP	CBL_PTK	1004:1013	Mutation altering degron motif	0.7229
p.I769V	HMV-II	skin	COSMIC	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation altering degron motif	0.7076
p.I769V	NEC8	testis	COSMIC	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation altering degron motif	0.7076
p.T767R	EKVX	lung	COSMIC	DSGVES	DEG_SCF_TRCP1_1	769:774	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM135A

UniProt ID: Q9P2D6

Entrez ID: 57579

Protein name: Protein FAM135A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM135A in