DegronMD

Uniprot ID: Q9P2D6

Source protein: Protein FAM135A

Source gene: FAM135A

Class: DEG_SCF_TRCP1_1

Location: 769:774

E3 ligase: BTRC

DEGRON score: 0.9522

ASA_SCORE: 86.05

COIL: 0.9057

CONS_SCORE: 0.4371

DSS_SCORE: 0.4778

HELIX: 0.0377

FCONS_SCORE: 1.3325

RIG_SCORE: 0.6271

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A780V	TCGA-2W-A8YY	CESC	TCGA	DSGVES	DEG_SCF_TRCP1_1	0.1667
p.A780V	DO223732	CESC	ICGC	DSGVES	DEG_SCF_TRCP1_1	0.1667
p.S778F	TCGA-AA-3977	COAD	TCGA	DSGVES	DEG_SCF_TRCP1_1	0.2222
p.R766T	TCGA-AG-4021	READ	TCGA	DSGVES	DEG_SCF_TRCP1_1	0.25
p.E775K	TCGA-BK-A0C9	UCEC	TCGA	DSGVES	DEG_SCF_TRCP1_1	0.3056
p.E775K	DO41253	UCEC	ICGC	DSGVES	DEG_SCF_TRCP1_1	0.3056
p.T761A	TCGA-DI-A1BU	UCEC	TCGA	DSGVES	DEG_SCF_TRCP1_1	0.1111
p.T761A	DO42023	UCEC	ICGC	DSGVES	DEG_SCF_TRCP1_1	0.1111
p.T765A	DO26442	LUSC	ICGC	DSGVES	DEG_SCF_TRCP1_1	0.2222
p.G766V	DO37462	SKCM	ICGC	DSGVES	DEG_SCF_TRCP1_1	0.25
p.I769V	HMV-II	skin	COSMIC	DSGVES	DEG_SCF_TRCP1_1	0.7076
p.I769V	NEC8	testis	COSMIC	DSGVES	DEG_SCF_TRCP1_1	0.7076
p.T767R	EKVX	lung	COSMIC	DSGVES	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12929	Epidermal growth factor receptor kinase substrate 8	DEG_SCF_TRCP1_1	810:815	DSGVES	BTRC	0.9892	More...
Q9P2D6	Protein FAM135A	DEG_SCF_TRCP1_1	769:774	DSGVES	BTRC	0.9522	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons