DegronMD

Uniprot ID: Q12929

Source protein: Epidermal growth factor receptor kinase substrate 8

Source gene: EPS8

Class: DEG_SCF_TRCP1_1

Location: 810:815

E3 ligase: BTRC

DEGRON score: 0.9892

ASA_SCORE: 85.95

COIL: 0.8587

CONS_SCORE: 0.324

DSS_SCORE: 0.6399

HELIX: 0.0925

FCONS_SCORE: 1.0329

RIG_SCORE: 0.6107

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F816S	TCGA-D1-A16I	UCEC	TCGA	DSGVES	DEG_SCF_TRCP1_1	0.3056
p.G819E	TCGA-D1-A17Q	UCEC	TCGA	DSGVES	DEG_SCF_TRCP1_1	0.2222
p.A807V	TCGA-FI-A2D5	UCEC	TCGA	DSGVES	DEG_SCF_TRCP1_1	0.25
p.R800Q	TCGA-W3-AA1V	SKCM	TCGA	DSGVES	DEG_SCF_TRCP1_1	0.0556
p.H822R	SIDM00680	Colorectal Carcinoma	GDSC	DSGVES	DEG_SCF_TRCP1_1	0.1389
p.H822R	LS-180	large_intestine	COSMIC	DSGVES	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12929	Epidermal growth factor receptor kinase substrate 8	DEG_SCF_TRCP1_1	810:815	DSGVES	BTRC	0.9892	More...
Q9P2D6	Protein FAM135A	DEG_SCF_TRCP1_1	769:774	DSGVES	BTRC	0.9522	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons