Degron: NLYSGTP
Mucin-16
MUC16
3295:3301
CBL
0.6152
83.6286
0.8829
0
0.5979
0.0176
0
0.6737
Degron related mutations and impact score
Mutation |
Sample |
Cancer |
Dataset |
Degron |
Degron class |
Impact score |
p.P3301T | TCGA-06-5416 | GBM | TCGA | NLYSGTP | CBL_PTK | 0.7031 |
p.P3301T | DO10880 | GBM | ICGC | NLYSGTP | CBL_PTK | 0.7031 |
p.L3285H | TCGA-55-8508 | LUAD | TCGA | NLYSGTP | CBL_PTK | 0.0556 |
p.L3285H | DO45341 | LUAD | ICGC | NLYSGTP | CBL_PTK | 0.0556 |
p.G3303E | TCGA-D3-A1QB | SKCM | TCGA | NLYSGTP | CBL_PTK | 0.2778 |
p.G3303E | DO47573 | SKCM | ICGC | NLYSGTP | CBL_PTK | 0.2778 |
p.L3285V | TCGA-IR-A3LA | CESC | TCGA | NLYSGTP | CBL_PTK | 0.0556 |
p.L3285V | DO44377 | CESC | ICGC | NLYSGTP | CBL_PTK | 0.0556 |
p.P3289L | TCGA-W3-AA1V | SKCM | TCGA | NLYSGTP | CBL_PTK | 0.1667 |
p.P3289L | DO51276 | SKCM | ICGC | NLYSGTP | CBL_PTK | 0.1667 |
p.G3299E | TCGA-W3-AA21 | SKCM | TCGA | NLYSGTP | CBL_PTK | 0.6087 |
p.G3299E | DO51278 | SKCM | ICGC | NLYSGTP | CBL_PTK | 0.6087 |
p.P3289T | DO229010 | COCA | ICGC | NLYSGTP | CBL_PTK | 0.1667 |
p.P3289T | DO229016 | COCA | ICGC | NLYSGTP | CBL_PTK | 0.1667 |
p.P3289T | DO229005 | COCA | ICGC | NLYSGTP | CBL_PTK | 0.1667 |
p.P3289T | DO234285 | ESAD | ICGC | NLYSGTP | CBL_PTK | 0.1667 |
p.P3289T | DO52365 | LUSC | ICGC | NLYSGTP | CBL_PTK | 0.1667 |
p.S3298Y | DO229018 | LICA | ICGC | NLYSGTP | CBL_PTK | 0.712 |
p.A3309D | DO229015 | LICA | ICGC | NLYSGTP | CBL_PTK | 0.1111 |
p.P3290H | DO229022 | LICA | ICGC | NLYSGTP | CBL_PTK | 0.1944 |
p.T3304I | DO229027 | LICA | ICGC | NLYSGTP | CBL_PTK | 0.25 |
p.S3286Y | DO229036 | LICA | ICGC | NLYSGTP | CBL_PTK | 0.0833 |
p.Q3306K | DO222458 | MELA | ICGC | NLYSGTP | CBL_PTK | 0.1944 |
p.G3302E | DO229453 | SKCA | ICGC | NLYSGTP | CBL_PTK | 0.3056 |
Drug responses associated with MUC16 mutations
Sample |
Cancer |
Mutation (In Degron?) |
Dataset |
Drug |
IC50 |
All proteins holding degron of NLYSGTP
Uniprot ID |
Source protein |
Degron class |
Location |
Hit |
E3 ligase |
Degron score |
Detail |
Q8WXI7 | Mucin-16 | CBL_PTK | 3295:3301 | NLYSGTP | CBL | 0.6152 | More... |