DegronMD

Uniprot ID: Q9HCM2

Source protein: Plexin-A4

Source gene: PLXNA4

Class: CBL_PTK

Location: 1623:1631

E3 ligase: CBL

DEGRON score: 0.9909

ASA_SCORE: 56.8444

COIL: 0.6656

CONS_SCORE: 0.4609

DSS_SCORE: 0.4576

HELIX: 0.1016

FCONS_SCORE: 1.0782

RIG_SCORE: 0.7303

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1619I	TCGA-17-Z055	LUAD	TCGA	NMIRYTGSP	CBL_PTK	0.2222
p.S1619I	TCGA-A5-A0G2	UCEC	TCGA	NMIRYTGSP	CBL_PTK	0.2222
p.S1619I	DO41235	UCEC	ICGC	NMIRYTGSP	CBL_PTK	0.2222
p.Y1627F	TCGA-37-4135	LUSC	TCGA	NMIRYTGSP	CBL_PTK	0.8639
p.Y1627F	DO26806	LUSC	ICGC	NMIRYTGSP	CBL_PTK	0.8639
p.D1632N	TCGA-A1-A0SF	BRCA	TCGA	NMIRYTGSP	CBL_PTK	0.3056
p.D1632N	DO1342	BRCA	ICGC	NMIRYTGSP	CBL_PTK	0.3056
p.R1635H	TCGA-AA-3680	COAD	TCGA	NMIRYTGSP	CBL_PTK	0.2222
p.R1635H	TCGA-AX-A05Z	UCEC	TCGA	NMIRYTGSP	CBL_PTK	0.2222
p.R1635H	TCGA-CD-A4MG	STAD	TCGA	NMIRYTGSP	CBL_PTK	0.2222
p.R1635H	DO9980	COAD	ICGC	NMIRYTGSP	CBL_PTK	0.2222
p.R1635H	DO48009	STAD	ICGC	NMIRYTGSP	CBL_PTK	0.2222
p.R1635H	DO40884	UCEC	ICGC	NMIRYTGSP	CBL_PTK	0.2222
p.R1615S	TCGA-AX-A2HC	UCEC	TCGA	NMIRYTGSP	CBL_PTK	0.1111
p.R1615S	TCGA-K4-A54R	BLCA	TCGA	NMIRYTGSP	CBL_PTK	0.1111
p.R1615S	DO48611	BLCA	ICGC	NMIRYTGSP	CBL_PTK	0.1111
p.R1615S	DO41572	UCEC	ICGC	NMIRYTGSP	CBL_PTK	0.1111
p.S1633I	TCGA-B5-A0JY	UCEC	TCGA	NMIRYTGSP	CBL_PTK	0.7222
p.S1633I	DO43041	UCEC	ICGC	NMIRYTGSP	CBL_PTK	0.7222
p.N1623S	TCGA-D1-A17Q	UCEC	TCGA	NMIRYTGSP	CBL_PTK	0.7069
p.N1623S	DO41903	UCEC	ICGC	NMIRYTGSP	CBL_PTK	0.7069
p.S1633N	TCGA-EE-A20H	SKCM	TCGA	NMIRYTGSP	CBL_PTK	0.7222
p.S1633N	DO37986	SKCM	ICGC	NMIRYTGSP	CBL_PTK	0.7222
p.L1634F	TCGA-EE-A2MR	SKCM	TCGA	NMIRYTGSP	CBL_PTK	0.25
p.L1634F	DO37819	SKCM	ICGC	NMIRYTGSP	CBL_PTK	0.25
p.R1637Q	TCGA-FW-A3R5	SKCM	TCGA	NMIRYTGSP	CBL_PTK	0.1667
p.R1637Q	DO37406	SKCM	ICGC	NMIRYTGSP	CBL_PTK	0.1667
p.M1624V	DO231031	LUSC	ICGC	NMIRYTGSP	CBL_PTK	0.6097
p.S1630I	SIDM00848	Ewing's Sarcoma	GDSC	NMIRYTGSP	CBL_PTK	0.7341
p.S1630I	ACH-000052	Bone Cancer	CCLE	NMIRYTGSP	CBL_PTK	0.7341
p.S1630I	A673	bone	COSMIC	NMIRYTGSP	CBL_PTK	0.7341
p.P1631S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	NMIRYTGSP	CBL_PTK	0.6752
p.P1631S	ACH-001233	Lung Cancer	CCLE	NMIRYTGSP	CBL_PTK	0.6752
p.P1631S	VMRC-LCD	lung	COSMIC	NMIRYTGSP	CBL_PTK	0.6752
p.R1615M	SIDM00934	Pancreatic Carcinoma	GDSC	NMIRYTGSP	CBL_PTK	0.1111
p.R1615M	ACH-000354	Pancreatic Cancer	CCLE	NMIRYTGSP	CBL_PTK	0.1111
p.R1615M	CAPAN-1	pancreas	COSMIC	NMIRYTGSP	CBL_PTK	0.1111
p.R1637W	ACH-001518	Endometrial/Uterine Cancer	CCLE	NMIRYTGSP	CBL_PTK	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NMIRYTGSP

Degron related mutations and impact score

Drug responses associated with PLXNA4 mutations

All proteins holding degron of NMIRYTGSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCM2	Plexin-A4	CBL_PTK	1623:1631	NMIRYTGSP	CBL	0.9909	More...