DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
NNPHASYSAPP
Uniprot ID:
Q7Z4V5
Source protein:
Hepatoma-derived growth factor-related protein 2
Source gene:
HDGFL2
Class:
CBL_PTK
Location:
86:96
E3 ligase:
CBL
DEGRON score:
0.796
ASA_SCORE:
68.4273
COIL:
0.815
CONS_SCORE:
0.4842
DSS_SCORE:
0.6569
HELIX:
0.148
FCONS_SCORE:
0.8858
RIG_SCORE:
0.5996
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.W82C
SIDM00217
Colorectal Carcinoma
GDSC
NNPHASYSAPP
CBL_PTK
0.2222
p.W82C
SNU-1040
large_intestine
COSMIC
NNPHASYSAPP
CBL_PTK
0.2222
p.A90T
SIDM00217
Colorectal Carcinoma
GDSC
NNPHASYSAPP
CBL_PTK
0.6028
p.A90T
SNU-1040
large_intestine
COSMIC
NNPHASYSAPP
CBL_PTK
0.6028
Drug responses associated with HDGFL2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NNPHASYSAPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z4V5
Hepatoma-derived growth factor-related protein 2
CBL_PTK
86:96
NNPHASYSAPP
CBL
0.796
More...
