DegronMD

Uniprot ID: Q9H1P3

Source protein: Oxysterol-binding protein-related protein 2

Source gene: OSBPL2

Class: CBL_PTK

Location: 453:460

E3 ligase: CBL

DEGRON score: 0.9394

ASA_SCORE: 77.1375

COIL: 0.8488

CONS_SCORE: 0.3712

DSS_SCORE: 0.263

HELIX: 0.0811

FCONS_SCORE: 0.8968

RIG_SCORE: 0.7243

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P451Q	TCGA-CR-7388	HNSC	TCGA	NNPYTGTP	CBL_PTK	0.2778
p.W448L	TCGA-FS-A1ZD	SKCM	TCGA	NNPYTGTP	CBL_PTK	0.1944
p.P455R	TCGA-WC-A87T	UVM	TCGA	NNPYTGTP	CBL_PTK	0.6401
p.R459Q	DO7962	COAD	ICGC	NNPYTGTP	CBL_PTK	0.7329
p.R459Q	A204	soft_tissue	COSMIC	NNPYTGTP	CBL_PTK	0.7329
p.D455Y	DO229015	LICA	ICGC	NNPYTGTP	CBL_PTK	0.7325
p.P465Q	DO37515	SKCM	ICGC	NNPYTGTP	CBL_PTK	0.1944
p.D466Y	DO42568	UCEC	ICGC	NNPYTGTP	CBL_PTK	0.1667
p.R459W	DO42633	UCEC	ICGC	NNPYTGTP	CBL_PTK	0.8634
p.Q445R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	NNPYTGTP	CBL_PTK	0.1111
p.Q445R	ACH-002272	Lymphoma	CCLE	NNPYTGTP	CBL_PTK	0.1111
p.Q445R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	NNPYTGTP	CBL_PTK	0.1111
p.D461N	SIDM01664	Prostate Carcinoma	GDSC	NNPYTGTP	CBL_PTK	0.3056
p.D461N	ACH-000952	Prostate Cancer	CCLE	NNPYTGTP	CBL_PTK	0.3056
p.W444C	ACH-000435	Endometrial/Uterine Cancer	CCLE	NNPYTGTP	CBL_PTK	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1P3	Oxysterol-binding protein-related protein 2	CBL_PTK	453:460	NNPYTGTP	CBL	0.9394	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons