DegronMD - Q9H1P3(OSBPL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F7L	TCGA-BK-A6W3	UCEC	TCGA	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.0556
p.F7L	DO50076	UCEC	ICGC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.0556
p.P451Q	TCGA-CR-7388	HNSC	TCGA	NNPYTGTP	CBL_PTK	453:460	Mutation rewiring degron network	0.2778
p.E25K	TCGA-CV-7095	HNSC	TCGA	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.25
p.W448L	TCGA-FS-A1ZD	SKCM	TCGA	NNPYTGTP	CBL_PTK	453:460	Mutation rewiring degron network	0.1944
p.P455R	TCGA-WC-A87T	UVM	TCGA	NNPYTGTP	CBL_PTK	453:460	Mutation altering degron motif	0.6401
p.R459Q	DO7962	COAD	ICGC	NNPYTGTP	CBL_PTK	453:460	Mutation altering degron motif	0.7329
p.R459Q	A204	soft tissue	COSMIC	NNPYTGTP	CBL_PTK	453:460	Mutation altering degron motif	0.7329
p.V18L	DO233202	GACA	ICGC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation altering degron motif	0.6765
p.D455Y	DO229015	LICA	ICGC	NNPYTGTP	CBL_PTK	453:460	Mutation altering degron motif	0.7325
p.P465Q	DO37515	SKCM	ICGC	NNPYTGTP	CBL_PTK	453:460	Mutation rewiring degron network	0.1944
p.D466Y	DO42568	UCEC	ICGC	NNPYTGTP	CBL_PTK	453:460	Mutation rewiring degron network	0.1667
p.R459W	DO42633	UCEC	ICGC	NNPYTGTP	CBL_PTK	453:460	Mutation altering degron motif	0.8634
p.Q445R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	NNPYTGTP	CBL_PTK	453:460	Mutation rewiring degron network	0.1111
p.Q445R	ACH-002272	Lymphoma	CCLE	NNPYTGTP	CBL_PTK	453:460	Mutation rewiring degron network	0.1111
p.Q445R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	NNPYTGTP	CBL_PTK	453:460	Mutation rewiring degron network	0.1111
p.A26T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2222
p.A26T	SIDM00257	Neuroblastoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2222
p.A26T	SIDM00720	Mesothelioma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2222
p.A26T	SIDM00760	Small Cell Lung Carcinoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2222
p.A26T	SIDM00628	Breast Carcinoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2222
p.A26T	SIDM01686	Chronic Myelogenous Leukemia	GDSC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2222
p.A26T	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2222
p.D461N	SIDM01664	Prostate Carcinoma	GDSC	NNPYTGTP	CBL_PTK	453:460	Mutation rewiring degron network	0.3056
p.D461N	ACH-000952	Prostate Cancer	CCLE	NNPYTGTP	CBL_PTK	453:460	Mutation rewiring degron network	0.3056
p.W444C	ACH-000435	Endometrial/Uterine Cancer	CCLE	NNPYTGTP	CBL_PTK	453:460	Mutation rewiring degron network	0.0833
p.R14Q	SNU-175	large intestine	COSMIC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.25
p.G24R	CP66-MEL	skin	COSMIC	DNSSGE	DEG_Kelch_Keap1_1	17:22	Mutation rewiring degron network	0.2778

Kaplan plot for OSBPL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OSBPL2

UniProt ID: Q9H1P3

Entrez ID: 9885

Protein name: Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OSBPL2 in