DegronMD

Uniprot ID: Q9H1P3

Source protein: Oxysterol-binding protein-related protein 2

Source gene: OSBPL2

Class: DEG_Kelch_Keap1_1

Location: 17:22

E3 ligase: KEAP1

DEGRON score: 0.99

ASA_SCORE: 89.65

COIL: 0.858

CONS_SCORE: 0.3929

DSS_SCORE: 0.527

HELIX: 0.115

FCONS_SCORE: 1.0253

RIG_SCORE: 0.6436

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F7L	TCGA-BK-A6W3	UCEC	TCGA	DNSSGE	DEG_Kelch_Keap1_1	0.0556
p.F7L	DO50076	UCEC	ICGC	DNSSGE	DEG_Kelch_Keap1_1	0.0556
p.E25K	TCGA-CV-7095	HNSC	TCGA	DNSSGE	DEG_Kelch_Keap1_1	0.25
p.V18L	DO233202	GACA	ICGC	DNSSGE	DEG_Kelch_Keap1_1	0.6765
p.A26T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	0.2222
p.A26T	SIDM00257	Neuroblastoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	0.2222
p.A26T	SIDM00720	Mesothelioma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	0.2222
p.A26T	SIDM00760	Small Cell Lung Carcinoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	0.2222
p.A26T	SIDM00628	Breast Carcinoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	0.2222
p.A26T	SIDM01686	Chronic Myelogenous Leukemia	GDSC	DNSSGE	DEG_Kelch_Keap1_1	0.2222
p.A26T	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	0.2222
p.R14Q	SNU-175	large_intestine	COSMIC	DNSSGE	DEG_Kelch_Keap1_1	0.25
p.G24R	CP66-MEL	skin	COSMIC	DNSSGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1P3	Oxysterol-binding protein-related protein 2	DEG_Kelch_Keap1_1	17:22	DNSSGE	KEAP1	0.99	More...
A6NNE9	E3 ubiquitin-protein ligase MARCHF11	DEG_Kelch_Keap1_1	389:394	DNSSGE	KEAP1	0.6178	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons