DegronMD

Uniprot ID: A6NNE9

Source protein: E3 ubiquitin-protein ligase MARCHF11

Source gene: MARCHF11

Class: DEG_Kelch_Keap1_1

Location: 389:394

E3 ligase: KEAP1

DEGRON score: 0.6178

ASA_SCORE: 77.4667

COIL: 0.8227

CONS_SCORE: 0.253

DSS_SCORE: 0.4905

HELIX: 0.0708

FCONS_SCORE: 0.9862

RIG_SCORE: 0.6642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S392L	SIDM00596	Endometrial Carcinoma	GDSC	DNSSGE	DEG_Kelch_Keap1_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1P3	Oxysterol-binding protein-related protein 2	DEG_Kelch_Keap1_1	17:22	DNSSGE	KEAP1	0.99	More...
A6NNE9	E3 ubiquitin-protein ligase MARCHF11	DEG_Kelch_Keap1_1	389:394	DNSSGE	KEAP1	0.6178	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons