DegronMD

Uniprot ID: Q8WZ73

Source protein: E3 ubiquitin-protein ligase rififylin

Source gene: RFFL

Class: CBL_PTK

Location: 31:38

E3 ligase: CBL

DEGRON score: 0.7458

ASA_SCORE: 67.375

COIL: 0.9288

CONS_SCORE: 0.3217

DSS_SCORE: 0.4618

HELIX: 0.0263

FCONS_SCORE: 1.0538

RIG_SCORE: 0.5978

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P32T	TCGA-20-1687	OV	TCGA	NPGYSSFP	CBL_PTK	0.5919
p.P32T	DO29668	OV	ICGC	NPGYSSFP	CBL_PTK	0.5919
p.S35I	TCGA-97-7938	LUAD	TCGA	NPGYSSFP	CBL_PTK	0.7341
p.S35I	DO24329	LUAD	ICGC	NPGYSSFP	CBL_PTK	0.7341
p.S36F	TCGA-AC-A2B8	BRCA	TCGA	NPGYSSFP	CBL_PTK	0.7982
p.S36F	DO5884	BRCA	ICGC	NPGYSSFP	CBL_PTK	0.7982
p.P32H	TCGA-DZ-6132	KIRP	TCGA	NPGYSSFP	CBL_PTK	0.6583
p.P32H	DO20919	KIRP	ICGC	NPGYSSFP	CBL_PTK	0.6583
p.G33W	TCGA-EE-A2MN	SKCM	TCGA	NPGYSSFP	CBL_PTK	0.6714
p.G33W	DO37423	SKCM	ICGC	NPGYSSFP	CBL_PTK	0.6714
p.E44G	TCGA-EY-A1G8	UCEC	TCGA	NPGYSSFP	CBL_PTK	0.1667
p.E44G	DO43578	UCEC	ICGC	NPGYSSFP	CBL_PTK	0.1667
p.Q27K	DO229041	LICA	ICGC	NPGYSSFP	CBL_PTK	0.2222
p.A24T	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	NPGYSSFP	CBL_PTK	0.1389
p.A24T	SIDM01574	Plasma Cell Myeloma	GDSC	NPGYSSFP	CBL_PTK	0.1389
p.A24T	ACH-000488	Esophageal Cancer	CCLE	NPGYSSFP	CBL_PTK	0.1389
p.A24T	ACH-000588	Myeloma	CCLE	NPGYSSFP	CBL_PTK	0.1389
p.K48E	SIDM00282	Colorectal Carcinoma	GDSC	NPGYSSFP	CBL_PTK	0.1667
p.K48E	ACH-000998	Colon/Colorectal Cancer	CCLE	NPGYSSFP	CBL_PTK	0.1667
p.K48E	CW-2	large_intestine	COSMIC	NPGYSSFP	CBL_PTK	0.1667
p.A24V	ACH-000928	Endometrial/Uterine Cancer	CCLE	NPGYSSFP	CBL_PTK	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ73	E3 ubiquitin-protein ligase rififylin	CBL_PTK	31:38	NPGYSSFP	CBL	0.7458	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons