DegronMD - Q8WZ73(RFFL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P235L	TCGA-06-1802	GBM	TCGA	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.2778
p.P32T	TCGA-20-1687	OV	TCGA	NPGYSSFP	CBL_PTK	31:38	Mutation altering degron motif	0.5919
p.P32T	DO29668	OV	ICGC	NPGYSSFP	CBL_PTK	31:38	Mutation altering degron motif	0.5919
p.S240C	TCGA-38-4630	LUAD	TCGA	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.7541
p.L241V	TCGA-4Z-AA81	BLCA	TCGA	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.6765
p.E230V	TCGA-95-7562	LUAD	TCGA	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.1389
p.S35I	TCGA-97-7938	LUAD	TCGA	NPGYSSFP	CBL_PTK	31:38	Mutation altering degron motif	0.7341
p.S35I	DO24329	LUAD	ICGC	NPGYSSFP	CBL_PTK	31:38	Mutation altering degron motif	0.7341
p.S36F	TCGA-AC-A2B8	BRCA	TCGA	NPGYSSFP	CBL_PTK	31:38	Mutation altering degron motif	0.7982
p.S36F	DO5884	BRCA	ICGC	NPGYSSFP	CBL_PTK	31:38	Mutation altering degron motif	0.7982
p.P32H	TCGA-DZ-6132	KIRP	TCGA	NPGYSSFP	CBL_PTK	31:38	Mutation altering degron motif	0.6583
p.P32H	DO20919	KIRP	ICGC	NPGYSSFP	CBL_PTK	31:38	Mutation altering degron motif	0.6583
p.G33W	TCGA-EE-A2MN	SKCM	TCGA	NPGYSSFP	CBL_PTK	31:38	Mutation altering degron motif	0.6714
p.G33W	DO37423	SKCM	ICGC	NPGYSSFP	CBL_PTK	31:38	Mutation altering degron motif	0.6714
p.E44G	TCGA-EY-A1G8	UCEC	TCGA	NPGYSSFP	CBL_PTK	31:38	Mutation rewiring degron network	0.1667
p.E44G	DO43578	UCEC	ICGC	NPGYSSFP	CBL_PTK	31:38	Mutation rewiring degron network	0.1667
p.S240P	TCGA-SJ-A6ZI	UCEC	TCGA	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.6752
p.R236H	DO233281	GACA	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.3056
p.R236H	DO41638	UCEC	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.3056
p.R236H	DO41871	UCEC	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.3056
p.R228Q	DO14750	HNSC	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.0833
p.Q27K	DO229041	LICA	ICGC	NPGYSSFP	CBL_PTK	31:38	Mutation rewiring degron network	0.2222
p.Q229K	DO229045	LICA	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation blocking phosphorylation signal	0.5556
p.Y241C	DO232761	PBCA	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.7087
p.T255I	DO41361	UCEC	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.0556
p.T255I	SK-OV-3	ovary	COSMIC	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation rewiring degron network	0.0556
p.A24T	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	NPGYSSFP	CBL_PTK	31:38	Mutation rewiring degron network	0.1389
p.A24T	SIDM01574	Plasma Cell Myeloma	GDSC	NPGYSSFP	CBL_PTK	31:38	Mutation rewiring degron network	0.1389
p.A24T	ACH-000488	Esophageal Cancer	CCLE	NPGYSSFP	CBL_PTK	31:38	Mutation rewiring degron network	0.1389
p.A24T	ACH-000588	Myeloma	CCLE	NPGYSSFP	CBL_PTK	31:38	Mutation rewiring degron network	0.1389
p.K48E	SIDM00282	Colorectal Carcinoma	GDSC	NPGYSSFP	CBL_PTK	31:38	Mutation substituting flanking lysine	0.1667
p.K48E	ACH-000998	Colon/Colorectal Cancer	CCLE	NPGYSSFP	CBL_PTK	31:38	Mutation substituting flanking lysine	0.1667
p.K48E	CW-2	large intestine	COSMIC	NPGYSSFP	CBL_PTK	31:38	Mutation substituting flanking lysine	0.1667
p.D243A	ACH-000294	Leukemia	CCLE	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.6682
p.D243A	NB-4	haematopoietic and lymphoid tissue	COSMIC	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation altering degron motif	0.6682
p.A24V	ACH-000928	Endometrial/Uterine Cancer	CCLE	NPGYSSFP	CBL_PTK	31:38	Mutation rewiring degron network	0.1389
p.Q229R	CW-2	large intestine	COSMIC	RRASLSDLT	DEG_APCC_DBOX_1	237:245	Mutation blocking phosphorylation signal	0.5556

Kaplan plot for RFFL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFFL

UniProt ID: Q8WZ73

Entrez ID: 117584

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFFL in