DegronMD

Uniprot ID: Q8WZ73

Source protein: E3 ubiquitin-protein ligase rififylin

Source gene: RFFL

Class: DEG_APCC_DBOX_1

Location: 237:245

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9994

ASA_SCORE: 82.3

COIL: 0.7318

CONS_SCORE: 0.5677

DSS_SCORE: 0.3627

HELIX: 0.1712

FCONS_SCORE: 1.1293

RIG_SCORE: 0.7276

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P235L	TCGA-06-1802	GBM	TCGA	RRASLSDLT	DEG_APCC_DBOX_1	0.2778
p.S240C	TCGA-38-4630	LUAD	TCGA	RRASLSDLT	DEG_APCC_DBOX_1	0.7541
p.L241V	TCGA-4Z-AA81	BLCA	TCGA	RRASLSDLT	DEG_APCC_DBOX_1	0.6765
p.E230V	TCGA-95-7562	LUAD	TCGA	RRASLSDLT	DEG_APCC_DBOX_1	0.1389
p.S240P	TCGA-SJ-A6ZI	UCEC	TCGA	RRASLSDLT	DEG_APCC_DBOX_1	0.6752
p.R236H	DO233281	GACA	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	0.3056
p.R236H	DO41638	UCEC	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	0.3056
p.R236H	DO41871	UCEC	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	0.3056
p.R228Q	DO14750	HNSC	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	0.0833
p.Q229K	DO229045	LICA	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	0.5556
p.Y241C	DO232761	PBCA	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	0.7087
p.T255I	DO41361	UCEC	ICGC	RRASLSDLT	DEG_APCC_DBOX_1	0.0556
p.T255I	SK-OV-3	ovary	COSMIC	RRASLSDLT	DEG_APCC_DBOX_1	0.0556
p.D243A	ACH-000294	Leukemia	CCLE	RRASLSDLT	DEG_APCC_DBOX_1	0.6682
p.D243A	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	RRASLSDLT	DEG_APCC_DBOX_1	0.6682
p.Q229R	CW-2	large_intestine	COSMIC	RRASLSDLT	DEG_APCC_DBOX_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ73	E3 ubiquitin-protein ligase rififylin	DEG_APCC_DBOX_1	237:245	RRASLSDLT	APC,CDC20,FZR1	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons