DegronMD

Uniprot ID: P05091

Source protein: Aldehyde dehydrogenase, mitochondrial

Source gene: ALDH2

Class: DEG_Kelch_Keap1_1

Location: 58:63

E3 ligase: KEAP1

DEGRON score: 0.9887

ASA_SCORE: 50.9833

COIL: 0.9398

CONS_SCORE: 0.6131

DSS_SCORE: 0.3469

HELIX: 0.0085

FCONS_SCORE: 1.1955

RIG_SCORE: 0.7342

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T56A	TCGA-BR-8591	STAD	TCGA	NPSTGE	DEG_Kelch_Keap1_1	0.2778
p.T56A	DO47973	STAD	ICGC	NPSTGE	DEG_Kelch_Keap1_1	0.2778
p.A48S	DO229028	LICA	ICGC	NPSTGE	DEG_Kelch_Keap1_1	0.0556
p.R51K	SIDM00175	Melanoma	GDSC	NPSTGE	DEG_Kelch_Keap1_1	0.1389
p.R51K	ACH-002096	Skin Cancer	CCLE	NPSTGE	DEG_Kelch_Keap1_1	0.1389
p.R51K	CP50-MEL-B	skin	COSMIC	NPSTGE	DEG_Kelch_Keap1_1	0.1389
p.A48V	SIDM00534	Colorectal Carcinoma	GDSC	NPSTGE	DEG_Kelch_Keap1_1	0.0556
p.A48V	ACH-000986	Colon/Colorectal Cancer	CCLE	NPSTGE	DEG_Kelch_Keap1_1	0.0556
p.A48V	HT-115	large_intestine	COSMIC	NPSTGE	DEG_Kelch_Keap1_1	0.0556
p.G71R	SIDM01617	Endometrial Carcinoma	GDSC	NPSTGE	DEG_Kelch_Keap1_1	0.1111
p.G71R	ACH-000994	Endometrial/Uterine Cancer	CCLE	NPSTGE	DEG_Kelch_Keap1_1	0.1111
p.T56I	ACH-000954	Endometrial/Uterine Cancer	CCLE	NPSTGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05091	Aldehyde dehydrogenase, mitochondrial	DEG_Kelch_Keap1_1	58:63	NPSTGE	KEAP1	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons