DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NPYSPNP
Uniprot ID:
Q9UKA2
Source protein:
F-box/LRR-repeat protein 4
Source gene:
FBXL4
Class:
CBL_PTK
Location:
160:166
E3 ligase:
CBL
DEGRON score:
0.9338
ASA_SCORE:
78.7286
COIL:
0.9513
CONS_SCORE:
0.2918
DSS_SCORE:
0.2133
HELIX:
0.0169
FCONS_SCORE:
0.5679
RIG_SCORE:
0.6839
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L175F
TCGA-D9-A148
SKCM
TCGA
NPYSPNP
CBL_PTK
0.0833
p.L175F
DO222711
ESCA
ICGC
NPYSPNP
CBL_PTK
0.0833
p.L175F
DO37971
SKCM
ICGC
NPYSPNP
CBL_PTK
0.0833
p.I152S
TCGA-DD-A39Z
LIHC
TCGA
NPYSPNP
CBL_PTK
0.1111
p.I152S
DO44954
LIHC
ICGC
NPYSPNP
CBL_PTK
0.1111
p.W172L
TCGA-E8-A2EA
THCA
TCGA
NPYSPNP
CBL_PTK
0.1667
p.W172L
DO38926
THCA
ICGC
NPYSPNP
CBL_PTK
0.1667
p.P166S
TCGA-EE-A17X
SKCM
TCGA
NPYSPNP
CBL_PTK
0.6752
p.P166S
DO37931
SKCM
ICGC
NPYSPNP
CBL_PTK
0.6752
p.Y162C
DO233652
GACA
ICGC
NPYSPNP
CBL_PTK
0.7087
p.P164Q
DO228971
LICA
ICGC
NPYSPNP
CBL_PTK
0.5924
p.A156T
DO27923
ORCA
ICGC
NPYSPNP
CBL_PTK
0.2222
p.N165H
ACH-001147
Lymphoma
CCLE
NPYSPNP
CBL_PTK
0.6312
Drug responses associated with FBXL4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPYSPNP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UKA2
F-box/LRR-repeat protein 4
CBL_PTK
160:166
NPYSPNP
CBL
0.9338
More...