DegronMD

Uniprot ID: Q9HAH7

Source protein: Probable fibrosin-1

Source gene: FBRS

Class: CBL_PTK

Location: 16:22

E3 ligase: CBL

DEGRON score: 0.9817

ASA_SCORE: 48.5429

COIL: 0.9194

CONS_SCORE: 0.2785

DSS_SCORE: 0.3494

HELIX: 0.0503

FCONS_SCORE: 0.9649

RIG_SCORE: 0.7359

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D19N	DO219729	CESC	ICGC	NPYTAFP	CBL_PTK	0.6932
p.G7E	DO48328	ESCA	ICGC	NPYTAFP	CBL_PTK	0.0833
p.G7E	DO52079	HNSC	ICGC	NPYTAFP	CBL_PTK	0.0833
p.M16I	DO231207	LUSC	ICGC	NPYTAFP	CBL_PTK	0.7618
p.R26W	DO27067	LUSC	ICGC	NPYTAFP	CBL_PTK	0.2222
p.P6Q	DO47451	SKCM	ICGC	NPYTAFP	CBL_PTK	0.0556
p.A24T	DO42033	UCEC	ICGC	NPYTAFP	CBL_PTK	0.2778
p.R14Q	DO42504	UCEC	ICGC	NPYTAFP	CBL_PTK	0.2778
p.L29I	DO42673	UCEC	ICGC	NPYTAFP	CBL_PTK	0.1389
p.C24Y	SIDM02026	Colorectal Carcinoma	GDSC	NPYTAFP	CBL_PTK	0.2778
p.P23H	ACH-000864	Endometrial/Uterine Cancer	CCLE	NPYTAFP	CBL_PTK	0.3056
p.P23H	COLO-684	endometrium	COSMIC	NPYTAFP	CBL_PTK	0.3056
p.R19C	ACH-000965	Endometrial/Uterine Cancer	CCLE	NPYTAFP	CBL_PTK	0.8301
p.P6S	ESO26	oesophagus	COSMIC	NPYTAFP	CBL_PTK	0.0556
p.P30L	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	NPYTAFP	CBL_PTK	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAH7	Probable fibrosin-1	CBL_PTK	16:22	NPYTAFP	CBL	0.9817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons