DegronMD

Uniprot ID: Q9UBU9

Source protein: Nuclear RNA export factor 1

Source gene: NXF1

Class: CBL_PTK

Location: 73:79

E3 ligase: CBL

DEGRON score: 0.9946

ASA_SCORE: 83.8857

COIL: 0.9437

CONS_SCORE: 0.2557

DSS_SCORE: 0.6261

HELIX: 0.0286

FCONS_SCORE: 0.9819

RIG_SCORE: 0.6884

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T76A	TCGA-09-2051	OV	TCGA	NPYTTRP	CBL_PTK	0.825
p.T76A	DO31450	OV	ICGC	NPYTTRP	CBL_PTK	0.825
p.D88N	TCGA-43-7658	LUSC	TCGA	NPYTTRP	CBL_PTK	0.0833
p.D88N	DO27628	LUSC	ICGC	NPYTTRP	CBL_PTK	0.0833
p.A64V	TCGA-91-6828	LUAD	TCGA	NPYTTRP	CBL_PTK	0.0833
p.A64V	DO26150	LUAD	ICGC	NPYTTRP	CBL_PTK	0.0833
p.R78L	TCGA-D1-A101	UCEC	TCGA	NPYTTRP	CBL_PTK	0.7316
p.R78L	DO43955	UCEC	ICGC	NPYTTRP	CBL_PTK	0.7316
p.H87R	TCGA-DF-A2KZ	UCEC	TCGA	NPYTTRP	CBL_PTK	0.1111
p.H87R	DO52409	UCEC	ICGC	NPYTTRP	CBL_PTK	0.1111
p.D84N	TCGA-EK-A3GK	CESC	TCGA	NPYTTRP	CBL_PTK	0.1944
p.D84N	DO49964	CESC	ICGC	NPYTTRP	CBL_PTK	0.1944
p.Q65H	TCGA-L9-A7SV	LUAD	TCGA	NPYTTRP	CBL_PTK	0.1111
p.Q65H	DO49875	LUAD	ICGC	NPYTTRP	CBL_PTK	0.1111
p.R81H	TCGA-VQ-A8PZ	STAD	TCGA	NPYTTRP	CBL_PTK	0.2778
p.R81H	DO51780	STAD	ICGC	NPYTTRP	CBL_PTK	0.2778
p.R81H	SIDM00999	Bladder Carcinoma	GDSC	NPYTTRP	CBL_PTK	0.2778
p.R81H	ACH-000973	Bladder Cancer	CCLE	NPYTTRP	CBL_PTK	0.2778
p.R81H	639-V	urinary_tract	COSMIC	NPYTTRP	CBL_PTK	0.2778
p.H87N	DO229027	LICA	ICGC	NPYTTRP	CBL_PTK	0.1111
p.R81C	DO222415	MELA	ICGC	NPYTTRP	CBL_PTK	0.2778
p.R69Q	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NPYTTRP	CBL_PTK	0.2222
p.G67V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	NPYTTRP	CBL_PTK	0.1667
p.G67V	ACH-002222	Leukemia	CCLE	NPYTTRP	CBL_PTK	0.1667
p.G67V	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	NPYTTRP	CBL_PTK	0.1667
p.R89Q	SIDM01619	Endometrial Carcinoma	GDSC	NPYTTRP	CBL_PTK	0.0556
p.R89Q	ACH-000984	Endometrial/Uterine Cancer	CCLE	NPYTTRP	CBL_PTK	0.0556
p.E73D	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	NPYTTRP	CBL_PTK	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBU9	Nuclear RNA export factor 1	CBL_PTK	73:79	NPYTTRP	CBL	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons