DegronMD - Q9UBU9(NXF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T76A	TCGA-09-2051	OV	TCGA	NPYTTRP	CBL_PTK	73:79	Mutation altering degron motif	0.825
p.T76A	DO31450	OV	ICGC	NPYTTRP	CBL_PTK	73:79	Mutation altering degron motif	0.825
p.D88N	TCGA-43-7658	LUSC	TCGA	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.0833
p.D88N	DO27628	LUSC	ICGC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.0833
p.A64V	TCGA-91-6828	LUAD	TCGA	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.0833
p.A64V	DO26150	LUAD	ICGC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.0833
p.R546I	TCGA-A5-A1OF	UCEC	TCGA	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.1111
p.R546I	TCGA-A5-A1OF	UCEC	TCGA	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation rewiring degron network	0.1944
p.R546I	DO42568	UCEC	ICGC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.1111
p.R546I	DO42568	UCEC	ICGC	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation rewiring degron network	0.1944
p.P551T	TCGA-B5-A3FC	UCEC	TCGA	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation altering degron motif	0.7031
p.P551T	DO41871	UCEC	ICGC	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation altering degron motif	0.7031
p.A549T	TCGA-B5-A3FC	UCEC	TCGA	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.1944
p.A549T	TCGA-B5-A3FC	UCEC	TCGA	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation rewiring degron network	0.2778
p.A549T	TCGA-OR-A5J5	ACC	TCGA	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.1944
p.A549T	TCGA-OR-A5J5	ACC	TCGA	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation rewiring degron network	0.2778
p.A549T	DO41871	UCEC	ICGC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.1944
p.A549T	DO41871	UCEC	ICGC	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation rewiring degron network	0.2778
p.A549T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.1944
p.A549T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation rewiring degron network	0.2778
p.A549T	ACH-001127	Leukemia	CCLE	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.1944
p.A549T	ACH-001127	Leukemia	CCLE	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation rewiring degron network	0.2778
p.A549T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.1944
p.A549T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation rewiring degron network	0.2778
p.R78L	TCGA-D1-A101	UCEC	TCGA	NPYTTRP	CBL_PTK	73:79	Mutation altering degron motif	0.7316
p.R78L	DO43955	UCEC	ICGC	NPYTTRP	CBL_PTK	73:79	Mutation altering degron motif	0.7316
p.H87R	TCGA-DF-A2KZ	UCEC	TCGA	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.1111
p.H87R	DO52409	UCEC	ICGC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.1111
p.D84N	TCGA-EK-A3GK	CESC	TCGA	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.1944
p.D84N	DO49964	CESC	ICGC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.1944
p.A573T	TCGA-FI-A2D5	UCEC	TCGA	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.0556
p.A573T	DO41331	UCEC	ICGC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.0556
p.Q65H	TCGA-L9-A7SV	LUAD	TCGA	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.1111
p.Q65H	DO49875	LUAD	ICGC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.1111
p.P561S	TCGA-PJ-A8JU	KIRP	TCGA	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation altering degron motif	0.6752
p.P561S	DO48523	KIRP	ICGC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation altering degron motif	0.6752
p.R81H	TCGA-VQ-A8PZ	STAD	TCGA	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.2778
p.R81H	DO51780	STAD	ICGC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.2778
p.R81H	SIDM00999	Bladder Carcinoma	GDSC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.2778
p.R81H	ACH-000973	Bladder Cancer	CCLE	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.2778
p.R81H	639-V	urinary tract	COSMIC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.2778
p.S558R	DO49675	LIAD	ICGC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation altering degron motif	0.7427
p.S558R	DO49675	LIAD	ICGC	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation altering degron motif	0.8538
p.S558R	DO22802	LICA	ICGC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation altering degron motif	0.7427
p.S558R	DO22802	LICA	ICGC	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation altering degron motif	0.8538
p.Q572K	DO228974	LICA	ICGC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation rewiring degron network	0.0833
p.H87N	DO229027	LICA	ICGC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.1111
p.R81C	DO222415	MELA	ICGC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.2778
p.S564F	SIDM01300	Colorectal Carcinoma	GDSC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation blocking phosphorylation signal	0.75
p.S564F	SIDM01300	Colorectal Carcinoma	GDSC	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation blocking phosphorylation signal	0.6111
p.R69Q	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.2222
p.P555S	SIDM00999	Bladder Carcinoma	GDSC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation altering degron motif	0.5641
p.P555S	SIDM00999	Bladder Carcinoma	GDSC	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation altering degron motif	0.6752
p.P555S	ACH-000973	Bladder Cancer	CCLE	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation altering degron motif	0.5641
p.P555S	ACH-000973	Bladder Cancer	CCLE	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation altering degron motif	0.6752
p.P555S	639-V	urinary tract	COSMIC	TPSSSPVPTL	DEG_COP1_1	554:563	Mutation altering degron motif	0.5641
p.P555S	639-V	urinary tract	COSMIC	PAPTPSSS	DEG_SCF_FBW7_1	551:558	Mutation altering degron motif	0.6752
p.G67V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.1667
p.G67V	ACH-002222	Leukemia	CCLE	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.1667
p.G67V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.1667
p.R89Q	SIDM01619	Endometrial Carcinoma	GDSC	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.0556
p.R89Q	ACH-000984	Endometrial/Uterine Cancer	CCLE	NPYTTRP	CBL_PTK	73:79	Mutation rewiring degron network	0.0556
p.E73D	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	NPYTTRP	CBL_PTK	73:79	Mutation altering degron motif	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NXF1

UniProt ID: Q9UBU9

Entrez ID: 10482

Protein name: Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NXF1 in