DegronMD

Uniprot ID: Q9UBU9

Source protein: Nuclear RNA export factor 1

Source gene: NXF1

Class: DEG_COP1_1

Location: 554:563

E3 ligase: COP1

DEGRON score: 0.9766

ASA_SCORE: 78.31

COIL: 0.948

CONS_SCORE: 0.4151

DSS_SCORE: 0.6713

HELIX: 0.0225

FCONS_SCORE: 1.0877

RIG_SCORE: 0.5812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R546I	TCGA-A5-A1OF	UCEC	TCGA	TPSSSPVPTL	DEG_COP1_1	0.1111
p.R546I	DO42568	UCEC	ICGC	TPSSSPVPTL	DEG_COP1_1	0.1111
p.A549T	TCGA-B5-A3FC	UCEC	TCGA	TPSSSPVPTL	DEG_COP1_1	0.1944
p.A549T	TCGA-OR-A5J5	ACC	TCGA	TPSSSPVPTL	DEG_COP1_1	0.1944
p.A549T	DO41871	UCEC	ICGC	TPSSSPVPTL	DEG_COP1_1	0.1944
p.A549T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	TPSSSPVPTL	DEG_COP1_1	0.1944
p.A549T	ACH-001127	Leukemia	CCLE	TPSSSPVPTL	DEG_COP1_1	0.1944
p.A549T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	TPSSSPVPTL	DEG_COP1_1	0.1944
p.A573T	TCGA-FI-A2D5	UCEC	TCGA	TPSSSPVPTL	DEG_COP1_1	0.0556
p.A573T	DO41331	UCEC	ICGC	TPSSSPVPTL	DEG_COP1_1	0.0556
p.P561S	TCGA-PJ-A8JU	KIRP	TCGA	TPSSSPVPTL	DEG_COP1_1	0.6752
p.P561S	DO48523	KIRP	ICGC	TPSSSPVPTL	DEG_COP1_1	0.6752
p.S558R	DO49675	LIAD	ICGC	TPSSSPVPTL	DEG_COP1_1	0.7427
p.S558R	DO22802	LICA	ICGC	TPSSSPVPTL	DEG_COP1_1	0.7427
p.Q572K	DO228974	LICA	ICGC	TPSSSPVPTL	DEG_COP1_1	0.0833
p.S564F	SIDM01300	Colorectal Carcinoma	GDSC	TPSSSPVPTL	DEG_COP1_1	0.75
p.P555S	SIDM00999	Bladder Carcinoma	GDSC	TPSSSPVPTL	DEG_COP1_1	0.5641
p.P555S	ACH-000973	Bladder Cancer	CCLE	TPSSSPVPTL	DEG_COP1_1	0.5641
p.P555S	639-V	urinary_tract	COSMIC	TPSSSPVPTL	DEG_COP1_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBU9	Nuclear RNA export factor 1	DEG_COP1_1	554:563	TPSSSPVPTL	COP1	0.9766	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons