DegronMD

Uniprot ID: Q9UBU9

Source protein: Nuclear RNA export factor 1

Source gene: NXF1

Class: DEG_SCF_FBW7_1

Location: 551:558

E3 ligase: FBXW7

DEGRON score: 0.9951

ASA_SCORE: 77.6875

COIL: 0.9528

CONS_SCORE: 0.4576

DSS_SCORE: 0.6094

HELIX: 0.0198

FCONS_SCORE: 1.3377

RIG_SCORE: 0.5664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R546I	TCGA-A5-A1OF	UCEC	TCGA	PAPTPSSS	DEG_SCF_FBW7_1	0.1944
p.R546I	DO42568	UCEC	ICGC	PAPTPSSS	DEG_SCF_FBW7_1	0.1944
p.P551T	TCGA-B5-A3FC	UCEC	TCGA	PAPTPSSS	DEG_SCF_FBW7_1	0.7031
p.P551T	DO41871	UCEC	ICGC	PAPTPSSS	DEG_SCF_FBW7_1	0.7031
p.A549T	TCGA-B5-A3FC	UCEC	TCGA	PAPTPSSS	DEG_SCF_FBW7_1	0.2778
p.A549T	TCGA-OR-A5J5	ACC	TCGA	PAPTPSSS	DEG_SCF_FBW7_1	0.2778
p.A549T	DO41871	UCEC	ICGC	PAPTPSSS	DEG_SCF_FBW7_1	0.2778
p.A549T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PAPTPSSS	DEG_SCF_FBW7_1	0.2778
p.A549T	ACH-001127	Leukemia	CCLE	PAPTPSSS	DEG_SCF_FBW7_1	0.2778
p.A549T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PAPTPSSS	DEG_SCF_FBW7_1	0.2778
p.S558R	DO49675	LIAD	ICGC	PAPTPSSS	DEG_SCF_FBW7_1	0.8538
p.S558R	DO22802	LICA	ICGC	PAPTPSSS	DEG_SCF_FBW7_1	0.8538
p.S564F	SIDM01300	Colorectal Carcinoma	GDSC	PAPTPSSS	DEG_SCF_FBW7_1	0.6111
p.P555S	SIDM00999	Bladder Carcinoma	GDSC	PAPTPSSS	DEG_SCF_FBW7_1	0.6752
p.P555S	ACH-000973	Bladder Cancer	CCLE	PAPTPSSS	DEG_SCF_FBW7_1	0.6752
p.P555S	639-V	urinary_tract	COSMIC	PAPTPSSS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBU9	Nuclear RNA export factor 1	DEG_SCF_FBW7_1	551:558	PAPTPSSS	FBXW7	0.9951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons