DegronMD

Uniprot ID: Q6P995

Source protein: Protein FAM171B

Source gene: FAM171B

Class: CBL_PTK

Location: 473:481

E3 ligase: CBL

DEGRON score: 0.9503

ASA_SCORE: 86.6556

COIL: 0.8298

CONS_SCORE: 0.4667

DSS_SCORE: 0.5682

HELIX: 0.1348

FCONS_SCORE: 0.9095

RIG_SCORE: 0.6899

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S478A	SIDM00284	Melanoma	GDSC	NQNNYSRNP	CBL_PTK	0.7588
p.S478A	COLO-679	skin	COSMIC	NQNNYSRNP	CBL_PTK	0.7588
p.N476S	TCGA-4R-AA8I	LIHC	TCGA	NQNNYSRNP	CBL_PTK	0.5958
p.N476S	DO49657	LIHC	ICGC	NQNNYSRNP	CBL_PTK	0.5958
p.V472F	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	NQNNYSRNP	CBL_PTK	0.3056
p.V472F	ACH-002337	Lung Cancer	CCLE	NQNNYSRNP	CBL_PTK	0.3056
p.T482I	SIDM01074	Glioblastoma	GDSC	NQNNYSRNP	CBL_PTK	0.3056
p.T482I	ACH-000102	Brain Cancer	CCLE	NQNNYSRNP	CBL_PTK	0.3056
p.T482I	GMS-10	central_nervous_system	COSMIC	NQNNYSRNP	CBL_PTK	0.3056
p.L470I	TCGA-19-5956	GBM	TCGA	NQNNYSRNP	CBL_PTK	0.25
p.L470I	DO13863	GBM	ICGC	NQNNYSRNP	CBL_PTK	0.25
p.D466N	DO234208	ESAD	ICGC	NQNNYSRNP	CBL_PTK	0.1389
p.D466H	ACH-000436	Myeloma	CCLE	NQNNYSRNP	CBL_PTK	0.1389
p.V489A	TCGA-AA-3663	COAD	TCGA	NQNNYSRNP	CBL_PTK	0.1111
p.V489A	DO9346	COAD	ICGC	NQNNYSRNP	CBL_PTK	0.1111
p.G490V	SIDM01316	Ewing's Sarcoma	GDSC	NQNNYSRNP	CBL_PTK	0.0833
p.G490V	ACH-000041	Bone Cancer	CCLE	NQNNYSRNP	CBL_PTK	0.0833

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P995	Protein FAM171B	CBL_PTK	473:481	NQNNYSRNP	CBL	0.9503	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons